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Literature summary extracted from

  • Picher, M.; Boucher, R.C.
    Biochemical evidence for an ecto alkaline phosphodiesterase I in human airways (2000), Am. J. Respir. Cell Mol. Biol., 23, 255-261.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.1 ADP-ribose competitive to diuridine tetraphosphate Homo sapiens
3.1.4.1 alpha,beta-methylene-adenosine triphosphate inhibition in decreasing order: alpha,beta-methyl-adenosine triphosphate, ATP, UTP, GTP, CTP Homo sapiens
3.1.4.1 ATP inhibition in decreasing order: alpha,beta-methylene-adenosine triphosphate, ATP, UTP, GTP, CTP Homo sapiens
3.1.4.1 CTP inhibition in decreasing order: alpha,beta-methylene-adenosine triphosphate, ATP, UTP, GTP, CTP Homo sapiens
3.1.4.1 fluoride
-
 Homo sapiens
3.1.4.1 GTP inhibition in decreasing order: alpha,beta-methylene-adenosine triphosphate, ATP, UTP, GTP, CTP Homo sapiens
3.1.4.1 additional information not inhibitory: 3-isobutyl-1methylxanthine, Ro 20-1724, 13-dipropyl-8-p-sulfophenylxanthine Homo sapiens
3.1.4.1 N-ethylmaleimide
-
 Homo sapiens
3.1.4.1 nucleoside 5'-triphosphate
-
 Homo sapiens
3.1.4.1 UTP inhibition in decreasing order: alpha,beta-methylene-adenosine triphosphate, ATP, UTP, GTP, CTP Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.1 0.022
-
 diuridine tetraphosphate pH 7.4, 37°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.1 membrane
-
 Homo sapiens 16020
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.1 epithelial cell of airway Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.1 ADP-ribose + H2O
-
 Homo sapiens ?
-
 ?
3.1.4.1 diadenosine polyphosphate + H2O
-
 Homo sapiens AMP + adenosine polyphosphate-1
-
 ?
3.1.4.1 P1,P4-bis(5'-uridyl) tetraphosphate + H2O
-
 Homo sapiens UMP + uridine 5'-triphosphate
-
 ?
3.1.4.1 thymidine 5'-monophosphate p-nitrophenylester + H2O
-
 Homo sapiens ? + phosphate
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.4.1 0.023
-
 ADP-ribose pH 7.4, 37°C Homo sapiens