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Literature summary extracted from

  • Komatsu, S.; Nishii, W.; Sasaki, H.; Muramatsu, T.; Tanokura, M.
    Substrate specificity of non-pepsin-type acid proteinase, Aspergillus niger proteinase A (1998), Adv. Exp. Med. Biol., 436, 345-348.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.23.19 additional information insensitive to pepstatin, diazoacetyl-DL-norleucine methyl ester, and 1,2-epoxy-3-(p-nitrophenoxy)propane Aspergillus niger

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.23.19 0.016
-
 RGFFHTPRA pH 1.8, 37°C Aspergillus niger
3.4.23.19 0.016
-
 RGFMTPRA pH 1.8, 37°C Aspergillus niger
3.4.23.19 0.07
-
 RGFFTPRA pH 1.8, 37°C Aspergillus niger
3.4.23.19 0.33
-
 RGFFYTPRA pH 1.8, 37°C Aspergillus niger

Organism

EC Number Organism UniProt Comment Textmining
3.4.23.19 Aspergillus niger
-
 var.macrosporus
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.23.19
-
 Aspergillus niger

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.23.19 additional information enzyme seems to cleave only peptides which contain large residues at p2 site, hardly influenced by the charges of the residues Aspergillus niger ?
-
 ?
3.4.23.19 RGFFHTPRA + H2O
-
 Aspergillus niger ?
-
 ?
3.4.23.19 RGFFTPRA + H2O
-
 Aspergillus niger ?
-
 ?
3.4.23.19 RGFFYTPRA + H2O
-
 Aspergillus niger ?
-
 ?
3.4.23.19 RGFMTPRA + H2O
-
 Aspergillus niger ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.23.19 Proteinase A
-
 Aspergillus niger

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.23.19 0.19
-
 RGFFHTPRA pH 1.8, 37°C Aspergillus niger
3.4.23.19 0.26
-
 RGFMTPRA pH 1.8, 37°C Aspergillus niger
3.4.23.19 0.48
-
 RGFFTPRA pH 1.8, 37°C Aspergillus niger
3.4.23.19 0.54
-
 RGFFYTPRA pH 1.8, 37°C Aspergillus niger
3.4.23.19 6.08
-
 RGFFYTPRA pH 1.8, 37°C Aspergillus niger