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Literature summary extracted from

  • Moore, B.S.; Eisenberg, R.; Weber, C.; Bridges, A.; Nanz, D.; Robinson, J.A.
    On the stereospecificity of the coenzyme B12-dependent isobutyryl-CoA mutase reaction (1995), J. Am. Chem. Soc., 117, 11285-11291.
No PubMed abstract available

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.4.99.13 2-methylpropanoyl-CoA Streptomyces virginiae biosynthesis of the antibiotic monesin-A butanoyl-CoA
-
 r
5.4.99.13 2-methylpropanoyl-CoA Streptomyces virginiae A3823.5 biosynthesis of the antibiotic monesin-A butanoyl-CoA
-
 r

Organism

EC Number Organism UniProt Comment Textmining
5.4.99.13 Streptomyces virginiae
-
 A3823.5
-
5.4.99.13 Streptomyces virginiae A3823.5
-
 A3823.5
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.4.99.13 partial, using ammonium sulfate precipitation, and DEAE-Sepharose column chromatography Streptomyces virginiae

Reaction

EC Number Reaction Comment Organism Reaction ID
5.4.99.13 2-methylpropanoyl-CoA = butanoyl-CoA loss of stereocontrol during the reaction Streptomyces virginiae
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.99.13 2-methylpropanoyl-CoA
-
 Streptomyces virginiae butanoyl-CoA
-
 r
5.4.99.13 2-methylpropanoyl-CoA biosynthesis of the antibiotic monesin-A Streptomyces virginiae butanoyl-CoA
-
 r
5.4.99.13 2-methylpropanoyl-CoA
-
 Streptomyces virginiae A3823.5 butanoyl-CoA
-
 r
5.4.99.13 2-methylpropanoyl-CoA biosynthesis of the antibiotic monesin-A Streptomyces virginiae A3823.5 butanoyl-CoA
-
 r
5.4.99.13 isobutyrylcarba(dethia)-CoA
-
 Streptomyces virginiae butyrylcarba(dethia)-CoA
-
 r
5.4.99.13 isobutyrylcarba(dethia)-CoA
-
 Streptomyces virginiae A3823.5 butyrylcarba(dethia)-CoA
-
 r

Synonyms

EC Number Synonyms Comment Organism
5.4.99.13 ICM
-
 Streptomyces virginiae

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
5.4.99.13 30
-
 the reaction is incubated at darkness Streptomyces virginiae
5.4.99.13 30
-
 assay at, half life of the mutase is of 60 min at 30ºC Streptomyces virginiae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
5.4.99.13 7.4
-
 assay at Streptomyces virginiae