Literature summary extracted from
Bracher, A.; Eisenreich, W.; Schramek, N.; Ritz, H.; Gotze, E.; Herrmann, A.; Gutlich, M.; Bacher, A.
Biosynthesis of pteridines. NMR studies on the reaction mechanisms of GTP cyclohydrolase I, pyruvoyltetrahydropterin synthase, and sepiapterin reductase (1998), J. Biol. Chem., 273, 28132-28141.
Cloned(Commentary)
EC Number |
Cloned (Comment) |
Organism |
---|
4.2.3.12 |
expression in Escherichia coli |
Homo sapiens |
Crystallization (Commentary)
EC Number |
Crystallization (Comment) |
Organism |
---|
4.2.3.12 |
X-ray crystallography |
Homo sapiens |
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
4.2.3.12 |
Homo sapiens |
- |
- |
- |
Purification (Commentary)
EC Number |
Purification (Comment) |
Organism |
---|
4.2.3.12 |
extraction, chromatography on an amylose resin column |
Homo sapiens |
Reaction
EC Number |
Reaction |
Comment |
Organism |
Reaction ID |
---|
4.2.3.12 |
7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate |
the enzyme catalyzes the elimination of triphosphate as well as a series of tautomerization reactions. Incorporation of protons into positions C6 and C3' of the product |
Homo sapiens |
|
Substrates and Products (Substrate)
EC Number |
Substrates |
Comment Substrates |
Organism |
Products |
Comment (Products) |
Rev. |
Reac. |
---|
4.2.3.12 |
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin |
- |
Homo sapiens |
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate |
- |
? |
|