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Literature summary extracted from

  • Cane, D.E.; Yang, G.; Xue, Q.; Shim, J.H.
    Trichodiene synthase. Substrate specificity and inhibition (1995), Biochemistry, 34, 2471-2479.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.3.6 10-fluorofarnesyl diphosphate
-
 Fusarium sporotrichioides
4.2.3.6 farnesyl diphosphate analogs 10-fluorofarnesyl diphosphate is the most effective competitive inhibitor Fusarium sporotrichioides

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.2.3.6 0.000036
-
 (Z,E)-farnesyl diphosphate pH 7.5 Fusarium sporotrichioides
4.2.3.6 0.000089
-
 (3R)-nerolidyl diphosphate pH 7.5 Fusarium sporotrichioides
4.2.3.6 0.00009
-
 (E,E)-farnesyl diphosphate pH 7.5 Fusarium sporotrichioides

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.3.6 (E,E)-farnesyl diphosphate Fusarium sporotrichioides
-
 trichodiene + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.3.6 Fusarium sporotrichioides
-
 recombinant enzyme from Escherichia coli BL21 DE3/pZW03
-
4.2.3.6 Fusarium sporotrichioides
-
 native enzyme
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.3.6 (3R)-nerolidyl diphosphate
-
 Fusarium sporotrichioides ?
-
 ?
4.2.3.6 (E,E)-farnesyl diphosphate
-
 Fusarium sporotrichioides trichodiene + diphosphate
-
 ?
4.2.3.6 (Z,E)-farnesyl diphosphate
-
 Fusarium sporotrichioides ?
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.2.3.6 0.000016
-
 10-fluorofarnesyl diphosphate pH 7.5 Fusarium sporotrichioides