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Literature summary extracted from

  • Li, H.; Xu, H.; Graham, D.E.; White, R.H.
    The Methanococcus jannaschii dCTP deaminase is a bifunctional deaminase and diphosphatase (2003), J. Biol. Chem., 278, 11100-11106.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.4.30
-
Methanocaldococcus jannaschii

Protein Variants

EC Number Protein Variants Comment Organism
3.5.4.30 E145Q no deaminase activity Methanocaldococcus jannaschii

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.30 dTTP 42% inhibition at 1 mM Methanocaldococcus jannaschii
3.5.4.30 dUTP 80% inhibition at 1 mM Methanocaldococcus jannaschii

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.4.30 17.6
-
dCTP 60°C, pH 7.5 Methanocaldococcus jannaschii

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.4.30 Mg2+ dependent on, optimal concentration: 2-5 mM Methanocaldococcus jannaschii
3.5.4.30 additional information requirement for divalent cation Methanocaldococcus jannaschii
3.5.4.30 NaCl maximum activity at 0.15 or 2 M Methanocaldococcus jannaschii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.30 dCTP + H2O Methanocaldococcus jannaschii
-
dUMP + diphosphate + NH3
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.30 Methanocaldococcus jannaschii Q57872
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.4.30
-
Methanocaldococcus jannaschii

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5.4.30 10.5
-
-
Methanocaldococcus jannaschii

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.30 dCTP + H2O
-
Methanocaldococcus jannaschii dUMP + diphosphate + NH3
-
?
3.5.4.30 additional information enzyme has also dUTP diphosphatase activity, dCTP deamination and dUTP diphosphatase activities occur independently at the same active site Methanocaldococcus jannaschii ?
-
?
3.5.4.30 additional information no substrates: dCMP, CTP, CDP, CMP, cytosine, deoxycytidine, ATP, dTTP, UTP and GTP Methanocaldococcus jannaschii ?
-
?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.5.4.30 90
-
thermostable, loss of 30% activity after 10 min Methanocaldococcus jannaschii

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.4.30 7.5
-
-
Methanocaldococcus jannaschii

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.5.4.30 6 9 50% activity at pH 6 and pH 9 Methanocaldococcus jannaschii