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Literature summary extracted from

  • Zong, Y.; Mazmanian, S.K.; Schneewind, O.; Narayana, S.V.L.
    The structure of sortase B, a cysteine transpeptidase that tethers surface protein to the Staphylococcus aureus cell wall (2004), Structure, 12, 105-112.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.4.22.71 hanging-drop vapor diffusion method. Crystal structure of SrtB-DELTA-N30 in complex with two active site inhibitors E64 and MTSET, and with the cell wall substrate analog tripleglycine Staphylococcus aureus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.71 IsdC + H2O Staphylococcus aureus the enzyme cleaves the C-terminal sorting signal of IsdC at the NPQTN motif and rethers the polypeptide to the pentaglycine cell wall cross-bridge. During catalysis, the active site cysteine of sortase and the cleaved substrate form an acyl intermediate, which is then resolved by the amino group of pentaglycine cross-bridges ?
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Organism

EC Number Organism UniProt Comment Textmining
3.4.22.71 Staphylococcus aureus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.71 IsdC + H2O the enzyme cleaves the C-terminal sorting signal of IsdC at the NPQTN motif and rethers the polypeptide to the pentaglycine cell wall cross-bridge. During catalysis, the active site cysteine of sortase and the cleaved substrate form an acyl intermediate, which is then resolved by the amino group of pentaglycine cross-bridges Staphylococcus aureus ?
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 ?