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Literature summary extracted from

  • Watt, K.W.K.; Lee, P.J.; M`Timkulu, T.; Chan, W.P.; Loor, R.
    Human prostate-specific antigen: structural and functional similarity with serine proteases (1986), Proc. Natl. Acad. Sci. USA, 83, 3166-3170.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.77 Aprotinin
-
 Homo sapiens
3.4.21.77 diisopropylfluorophosphate
-
 Homo sapiens
3.4.21.77 L-1-tosylamido-2-phenylethyl chloromethyl ketone
-
 Homo sapiens
3.4.21.77 leupeptin
-
 Homo sapiens
3.4.21.77 PMSF
-
 Homo sapiens
3.4.21.77 Soybean trypsin inhibitor
-
 Homo sapiens
3.4.21.77 spermidine
-
 Homo sapiens
3.4.21.77 Zn2+
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.21.77 15.3
-
 N-succinyl-L-Ala-L-Ala-L-Pro-L-Phe 4-nitroanilide
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.77 26500
-
 calculation from amino acid sequence Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.77 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.77 glycoprotein an N-linked carbohydrate side chain is predicted at Asp45, and O-linked carbohydrate side chains are possibly attached to Ser69, Thr70 and Ser71 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.77 seminal plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.77 N-alpha-benzoyl-DL-Arg 4-nitroanilide + H2O trypsin-like activity Homo sapiens N-alpha-benzoyl-DL-Arg + 4-nitroaniline
-
 ?
3.4.21.77 N-succinyl-L-Ala-L-Ala-L-Pro-L-Phe 4-nitroanilide + H2O chymotrypsin-like activity Homo sapiens N-succinyl-L-Ala-L-Ala-L-Pro-L-Phe + 4-nitroaniline
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.21.77 0.075
-
 N-succinyl-L-Ala-L-Ala-L-Pro-L-Phe 4-nitroanilide
-
 Homo sapiens