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Literature summary extracted from

  • Ton-That, H.; Liu, G.; Mazmanian, S.K.; Faull, K.F.; Schneewind, O.
    Purification and characterization of sortase, the transpeptidase that cleaves surface proteins of Staphylococcus aureus at the LPXTG motif (1999), Proc. Natl. Acad. Sci. USA, 96, 12424-12429.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.4.22.70 C184A mutant enzyme can not cleave the LPXTG motif Staphylococcus aureus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.70 additional information Staphylococcus aureus the enzyme cleaves surface proteins of Staphylococcus aureus at the LPXT-/-G motif, catalyzes surface protein anchoring by means of a transpeptidation reaction that captures cleaved polypeptides as thioester enzyme intermediates ?
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?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.70 Staphylococcus aureus
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-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.22.70
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Staphylococcus aureus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.70 4-[[4'-(dimethylamino)phenyl]azo]-benzoyl-Gln-Ala-Leu-Pro-Glu-Thr-Gly-Glu-Glu-5-[(2'-aminoethyl)-amino]naphthalenesulfonic acid + H2O
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Staphylococcus aureus 4-[[4'-(dimethylamino)phenyl]azo]-benzoyl-Gln-Ala-Leu-Pro-Glu-Thr + Gly-Glu-Glu-5-[(2'-aminoethyl)-amino]naphthalenesulfonic acid
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?
3.4.22.70 additional information the enzyme cleaves surface proteins of Staphylococcus aureus at the LPXT-/-G motif Staphylococcus aureus ?
-
?
3.4.22.70 additional information the enzyme cleaves surface proteins of Staphylococcus aureus at the LPXT-/-G motif, catalyzes surface protein anchoring by means of a transpeptidation reaction that captures cleaved polypeptides as thioester enzyme intermediates Staphylococcus aureus ?
-
?