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Literature summary extracted from
- Golgi alpha-mannosidase II deficiency in vertebrate systems: implications for asparagine-linked oligosaccharide processing in mammals (2002), Biochim. Biophys. Acta, 1573, 225-235.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.2.1.114 | medicine | enzyme deficiency causes congenital dyserythropoietic anemia with splenomegaly and various additional abnormalities and complications | Mus musculus |
| 3.2.1.114 | medicine | enzyme deficiency causes congenital dyserythropoietic anemia with splenomegaly and various additional abnormalities and complications | Homo sapiens |
| 3.2.1.114 | medicine | reduced expression of Man II in the autosomal genetic HEMPAS disease, i.e. hereditary erythroblastic multinuclearity associated with positive acidified serum | Homo sapiens |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.2.1.114 | Golgi mannosidase II gene is located on chromosome 5q21, Golgi mannosidase IIx on chromosome 15q25 | Homo sapiens |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 3.2.1.114 | additional information | mutants without GlcNAc(Man)5(GlcNAc)2 activity, Golgi mannosidase II-null mice phenotype | Mus musculus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.2.1.114 | 1,4-Dideoxy-1,4-imino-D-mannitol | - |
Homo sapiens |  |
| 3.2.1.114 | 1,4-Dideoxy-1,4-imino-D-mannitol | - |
Mus musculus | |
| 3.2.1.114 | 1,4-Dideoxy-1,4-imino-D-mannitol | - |
Rattus norvegicus | |
| 3.2.1.114 | swainsonine | - |
Drosophila melanogaster | |
| 3.2.1.114 | swainsonine | - |
Homo sapiens | |
| 3.2.1.114 | swainsonine | - |
Mus musculus | |
| 3.2.1.114 | swainsonine | - |
Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.2.1.114 | Golgi apparatus | - |
Drosophila melanogaster | 5794 | - |
| 3.2.1.114 | Golgi apparatus | - |
Mus musculus | 5794 | - |
| 3.2.1.114 | Golgi apparatus | - |
Rattus norvegicus | 5794 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.2.1.114 | Zn2+ | - |
Rattus norvegicus | |
| 3.2.1.114 | Zn2+ | active site coordination to Zn2+ | Drosophila melanogaster | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.2.1.114 | additional information | Drosophila melanogaster | - |
? | - |
? | |
| 3.2.1.114 | additional information | Rattus norvegicus | - |
? | - |
? | |
| 3.2.1.114 | additional information | Mus musculus | involved in trimming reactions in N-glycan maturation in the Golgi complex | ? | - |
? | |
| 3.2.1.114 | additional information | Homo sapiens | involved in trimming reactions in N-glycan maturation in the Golgi complex | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.2.1.114 | Drosophila melanogaster | - |
- |
- |
| 3.2.1.114 | Homo sapiens | - |
- |
- |
| 3.2.1.114 | Mus musculus | - |
- |
- |
| 3.2.1.114 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.2.1.114 | liver | - |
Mus musculus | - |
| 3.2.1.114 | liver | - |
Homo sapiens | - |
| 3.2.1.114 | liver | rat | Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.2.1.114 | 4-nitrophenyl alpha-D-mannoside + H2O | - |
Drosophila melanogaster | 4-nitrophenol + alpha-D-mannose | - |
? | |
| 3.2.1.114 | 4-nitrophenyl alpha-D-mannoside + H2O | - |
Homo sapiens | 4-nitrophenol + alpha-D-mannose | - |
? | |
| 3.2.1.114 | 4-nitrophenyl alpha-D-mannoside + H2O | rat | Rattus norvegicus | 4-nitrophenol + alpha-D-mannose | - |
? | |
| 3.2.1.114 | D-Manalpha(1-6)(Manalpha(1-3))Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + H2O | - |
Mus musculus | D-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + alpha-D-mannose | - |
? | |
| 3.2.1.114 | D-Manalpha(1-6)(Manalpha(1-3))Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + H2O | - |
Homo sapiens | D-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + alpha-D-mannose | - |
? | |
| 3.2.1.114 | D-Manalpha(1-6)(Manalpha(1-3))Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + H2O | - |
Rattus norvegicus | D-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + alpha-D-mannose | - |
? | |
| 3.2.1.114 | additional information | - |
Drosophila melanogaster | ? | - |
? | |
| 3.2.1.114 | additional information | - |
Rattus norvegicus | ? | - |
? | |
| 3.2.1.114 | additional information | involved in trimming reactions in N-glycan maturation in the Golgi complex | Mus musculus | ? | - |
? | |
| 3.2.1.114 | additional information | involved in trimming reactions in N-glycan maturation in the Golgi complex | Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.2.1.114 | Golgi mannosidase IIx | close homolog to Golgi mannosidase II with different substrate specificity | Mus musculus |
| 3.2.1.114 | Golgi mannosidase IIx | close homolog to Golgi mannosidase II with different substrate specificity | Homo sapiens |
| 3.2.1.114 | More | member of glycosyl hydrolase family 38 | Drosophila melanogaster |
| 3.2.1.114 | More | member of glycosyl hydrolase family 38 | Mus musculus |
| 3.2.1.114 | More | member of glycosyl hydrolase family 38 | Homo sapiens |
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Release 2023.1 (January 2023)
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