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Literature summary extracted from
- Comparison of purified human and rabbit serum paraoxonases (1995), Drug Metab. Dispos., 23, 935-944.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.2 | cardiolipin | stimulates | Oryctolagus cuniculus |  |
| 3.1.1.2 | dilauroyl phosphatidylcholine | stimulates | Homo sapiens | |
| 3.1.1.2 | dimyristoyl phosphatidylcholine | stimulates | Homo sapiens | |
| 3.1.1.2 | dimyristoyl phosphatidylcholine | stimulates | Oryctolagus cuniculus | |
| 3.1.1.2 | dioleoyl phosphatidylcholine | stimulates | Homo sapiens | |
| 3.1.1.2 | dioleoyl phosphatidylcholine | stimulates | Oryctolagus cuniculus | |
| 3.1.1.2 | lecithin | stimulates | Homo sapiens | |
| 3.1.1.2 | lecithin | stimulates | Oryctolagus cuniculus | |
| 3.1.1.2 | lysolecithin | stimulates | Homo sapiens | |
| 3.1.1.2 | lysolecithin | stimulates | Oryctolagus cuniculus | |
| 3.1.1.2 | phosphatidylethanolamine | stimulates | Homo sapiens | |
| 3.1.1.2 | phosphatidylethanolamine | stimulates | Oryctolagus cuniculus | |
| 3.1.1.2 | phosphatidylglycerol | stimulates | Oryctolagus cuniculus | |
| 3.1.1.2 | phosphatidylsenine | stimulates | Oryctolagus cuniculus | |
| 3.1.1.2 | sphingomyelin | stimulates | Oryctolagus cuniculus | |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.2 | EDTA | - |
Homo sapiens | |
| 3.1.1.2 | EDTA | - |
Oryctolagus cuniculus | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.2 | Ca2+ | Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+, two Ca2+ binding sites | Homo sapiens | |
| 3.1.1.2 | Ca2+ | Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+, two Ca2+ binding sites | Oryctolagus cuniculus | |
| 3.1.1.2 | Cd2+ | Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+ | Homo sapiens | |
| 3.1.1.2 | Cd2+ | Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+ | Oryctolagus cuniculus | |
| 3.1.1.2 | Zn2+ | Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+ | Homo sapiens | |
| 3.1.1.2 | Zn2+ | Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+ | Oryctolagus cuniculus | |
| 3.1.8.1 | Ca2+ | Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+, two Ca2+ binding sites | Homo sapiens | |
| 3.1.8.1 | Ca2+ | Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+, two Ca2+ binding sites | Oryctolagus cuniculus | |
| 3.1.8.1 | Cd2+ | Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+ | Homo sapiens | |
| 3.1.8.1 | Cd2+ | Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+ | Oryctolagus cuniculus | |
| 3.1.8.1 | Zn2+ | Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+ | Homo sapiens | |
| 3.1.8.1 | Zn2+ | Ca2+ is required for catalytic activity and structural stability. Cd2+ or Zn2+ substitute for Ca2+ | Oryctolagus cuniculus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.2 | 39800 | - |
rabbit serum contains two major species of PON monomers (42300 Da and 39800 Da), SDS-PAGE | Oryctolagus cuniculus |
| 3.1.1.2 | 42300 | - |
rabbit serum contains two major species of PON monomers (42300 Da and 39800 Da), SDS-PAGE | Oryctolagus cuniculus |
| 3.1.8.1 | additional information | - |
rabbit serum contains two major species of PON monomers (42300 Da and 39800 Da), SDS-PAGE | Oryctolagus cuniculus |
| 3.1.8.1 | 40600 | - |
human serum contains one major species of PON monomer (44300 Da) and a minor species of PON monomer (40600 kDa) | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.1.2 | Homo sapiens | - |
- |
- |
| 3.1.1.2 | Oryctolagus cuniculus | - |
- |
- |
| 3.1.8.1 | Homo sapiens | - |
- |
- |
| 3.1.8.1 | Oryctolagus cuniculus | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.1.1.2 | glycoprotein | at least 2 N-linked sugar chains, contains sialic acid residues | Homo sapiens |
| 3.1.1.2 | glycoprotein | at least 2 N-linked sugar chains, contains sialic acid residues | Oryctolagus cuniculus |
| 3.1.8.1 | glycoprotein | at least 2 N-linked sugar chains, contains sialic acid residues | Homo sapiens |
| 3.1.8.1 | glycoprotein | at least 2 N-linked sugar chains, contains sialic acid residues | Oryctolagus cuniculus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.1.2 | blood serum | - |
Oryctolagus cuniculus | - |
| 3.1.1.2 | blood serum | contains A-type paraoxonase and B-type paraoxonase | Homo sapiens | - |
| 3.1.8.1 | blood serum | - |
Oryctolagus cuniculus | - |
| 3.1.8.1 | blood serum | contains A-type paraoxonase and B-type paraoxonase | Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.2 | 1-naphthyl acetate + H2O | 0.1% of the activity with phenyl acetate | Oryctolagus cuniculus | 1-naphthol + acetate | - |
? | |
| 3.1.1.2 | 1-naphthyl acetate + H2O | 0.1% of the activity with phenyl acetate, A-type enzyme. 0.25% of the activity with phenyl acetate, B-type enzyme | Homo sapiens | 1-naphthol + acetate | - |
? | |
| 3.1.1.2 | 2-naphthyl acetate + H2O | 13.5% of the activity with phenyl acetate | Oryctolagus cuniculus | 2-naphthol + acetate | - |
? | |
| 3.1.1.2 | 2-naphthyl acetate + H2O | 5.5% of the activity with phenyl acetate, A-type enzyme. 7% of the activity with phenyl acetate, B-type enzyme | Homo sapiens | 2-naphthol + acetate | - |
? | |
| 3.1.1.2 | 2-nitrophenyl acetate + H2O | 2.1% of the activity with phenyl acetate, A-type enzyme. 2% of the activity with phenyl acetate, B-type enzyme | Homo sapiens | 2-nitrophenol + acetate | - |
? | |
| 3.1.1.2 | 2-nitrophenyl acetate + H2O | 29% of the activity with phenyl acetate | Oryctolagus cuniculus | 2-nitrophenol + acetate | - |
? | |
| 3.1.1.2 | 4-nitrophenyl acetate + H2O | 2.5% of the activity with phenyl acetate, A-type enzyme. 3.5% of the activity with phenyl acetate, B-type enzyme | Homo sapiens | 4-nitrophenol + acetate | - |
? | |
| 3.1.1.2 | 4-nitrophenyl acetate + H2O | 31% of the activity with phenyl acetate | Oryctolagus cuniculus | 4-nitrophenol + acetate | - |
? | |
| 3.1.1.2 | phenyl acetate + H2O | - |
Homo sapiens | phenol + acetate | - |
? | |
| 3.1.1.2 | phenyl acetate + H2O | - |
Oryctolagus cuniculus | phenol + acetate | - |
? | |
| 3.1.1.2 | thiophenyl acetate + H2O | 27% of the activity with phenyl acetate, A-type enzyme. 34% of the activity with phenyl acetate, B-type enzyme | Homo sapiens | ? | - |
? | |
| 3.1.1.2 | thiophenyl acetate + H2O | 30.5% of the activity with phenyl acetate | Oryctolagus cuniculus | ? | - |
? | |
| 3.1.8.1 | paraoxon + H2O | 0.2% of the activity with phenyl acetate | Oryctolagus cuniculus | diethylphosphate + 4-nitrophenol | - |
? | |
| 3.1.8.1 | paraoxon + H2O | A-type paraoxonase shows 0.06% of the activity with phenyl acetate, B-type paraoxonase shows 2.5% of the activity with phenyl acetate | Homo sapiens | diethylphosphate + 4-nitrophenol | - |
? | |
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