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Literature summary extracted from

  • Low, M.G.; Prasad, A.R.S.
    A phospholipase D specific for the phosphatidylinositol anchor of cell-surface proteins is abundant in plasma (1988), Proc. Natl. Acad. Sci. USA, 85, 980-984.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.50 n-butanol
-
 Oryctolagus cuniculus
3.1.4.50 n-butanol activation, at pH 5, membrane form of variant-surface-glycoprotein as substrate Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.50 1,10-phenanthroline
-
 Bos taurus
3.1.4.50 1,10-phenanthroline more effective than EGTA Homo sapiens
3.1.4.50 1,10-phenanthroline more effective than EGTA Oryctolagus cuniculus
3.1.4.50 1,10-phenanthroline more effective than EGTA Rattus norvegicus
3.1.4.50 EGTA
-
 Bos taurus
3.1.4.50 EGTA Ca2+ partially reverses Homo sapiens
3.1.4.50 EGTA Ca2+ partially reverses Oryctolagus cuniculus
3.1.4.50 EGTA Ca2+ partially reverses Rattus norvegicus
3.1.4.50 additional information no inhibition by leupeptin Homo sapiens
3.1.4.50 additional information no inhibition by leupeptin; no inhibition by PMSF Oryctolagus cuniculus
3.1.4.50 additional information no inhibition by leupeptin; no inhibition by PMSF Rattus norvegicus
3.1.4.50 p-Hydroxymercuriphenylsulfonic acid
-
 Homo sapiens
3.1.4.50 p-Hydroxymercuriphenylsulfonic acid
-
 Oryctolagus cuniculus
3.1.4.50 p-Hydroxymercuriphenylsulfonic acid
-
 Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.50 Ca2+ activation Homo sapiens
3.1.4.50 Ca2+ activation Rattus norvegicus
3.1.4.50 Ca2+ activation Bos taurus
3.1.4.50 Ca2+ activation Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.50 membrane form of variant-surface-glycoprotein + H2O Gallus gallus
-
 phosphatidic acid + variant-surface-glycoprotein inositol
-
 ?
3.1.4.50 membrane form of variant-surface-glycoprotein + H2O Homo sapiens
-
 phosphatidic acid + variant-surface-glycoprotein inositol
-
 ?
3.1.4.50 membrane form of variant-surface-glycoprotein + H2O Rattus norvegicus
-
 phosphatidic acid + variant-surface-glycoprotein inositol
-
 ?
3.1.4.50 membrane form of variant-surface-glycoprotein + H2O Bos taurus
-
 phosphatidic acid + variant-surface-glycoprotein inositol
-
 ?
3.1.4.50 membrane form of variant-surface-glycoprotein + H2O Oryctolagus cuniculus
-
 phosphatidic acid + variant-surface-glycoprotein inositol
-
 ?
3.1.4.50 membrane form of variant-surface-glycoprotein + H2O Canis lupus familiaris
-
 phosphatidic acid + variant-surface-glycoprotein inositol
-
 ?
3.1.4.50 membrane form of variant-surface-glycoprotein + H2O Equus caballus
-
 phosphatidic acid + variant-surface-glycoprotein inositol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.50 Bos taurus
-
 fetus
-
3.1.4.50 Canis lupus familiaris
-
-
-
3.1.4.50 Equus caballus
-
-
-
3.1.4.50 Gallus gallus
-
-
-
3.1.4.50 Homo sapiens
-
-
-
3.1.4.50 Oryctolagus cuniculus
-
-
-
3.1.4.50 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.4.50 partial Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.50 placenta
-
 Homo sapiens
-
3.1.4.50 plasma
-
 Bos taurus
-
3.1.4.50 plasma heparinized Homo sapiens
-
3.1.4.50 plasma heparinized Rattus norvegicus
-
3.1.4.50 plasma heparinized Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.50 5'-nucleotidase + H2O isolated from rat liver Rattus norvegicus ?
-
 ?
3.1.4.50 5'-nucleotidase + H2O isolated from rat liver Oryctolagus cuniculus ?
-
 ?
3.1.4.50 alkaline phosphatase + H2O isolated from human placenta Rattus norvegicus ?
-
 ?
3.1.4.50 alkaline phosphatase + H2O isolated from human placenta Oryctolagus cuniculus ?
-
 ?
3.1.4.50 membrane form of variant-surface-glycoprotein + H2O
-
 Gallus gallus phosphatidic acid + variant-surface-glycoprotein inositol
-
 ?
3.1.4.50 membrane form of variant-surface-glycoprotein + H2O
-
 Homo sapiens phosphatidic acid + variant-surface-glycoprotein inositol
-
 ?
3.1.4.50 membrane form of variant-surface-glycoprotein + H2O
-
 Rattus norvegicus phosphatidic acid + variant-surface-glycoprotein inositol
-
 ?
3.1.4.50 membrane form of variant-surface-glycoprotein + H2O
-
 Bos taurus phosphatidic acid + variant-surface-glycoprotein inositol
-
 ?
3.1.4.50 membrane form of variant-surface-glycoprotein + H2O
-
 Oryctolagus cuniculus phosphatidic acid + variant-surface-glycoprotein inositol
-
 ?
3.1.4.50 membrane form of variant-surface-glycoprotein + H2O
-
 Canis lupus familiaris phosphatidic acid + variant-surface-glycoprotein inositol
-
 ?
3.1.4.50 membrane form of variant-surface-glycoprotein + H2O
-
 Equus caballus phosphatidic acid + variant-surface-glycoprotein inositol
-
 ?
3.1.4.50 membrane form of variant-surface-glycoprotein + H2O specific for glycosyl-phosphatidylinositol structure, i.e. the anchoring domain of cell surface proteins Homo sapiens phosphatidic acid + variant-surface-glycoprotein inositol
-
 ?
3.1.4.50 membrane form of variant-surface-glycoprotein + H2O specific for glycosyl-phosphatidylinositol structure, i.e. the anchoring domain of cell surface proteins Rattus norvegicus phosphatidic acid + variant-surface-glycoprotein inositol dimyristoylphosphatidic acid ?
3.1.4.50 membrane form of variant-surface-glycoprotein + H2O specific for glycosyl-phosphatidylinositol structure, i.e. the anchoring domain of cell surface proteins Oryctolagus cuniculus phosphatidic acid + variant-surface-glycoprotein inositol dimyristoylphosphatidic acid ?
3.1.4.50 membrane form of variant-surface-glycoprotein + H2O phospholipase D-type hydrolysis Gallus gallus phosphatidic acid + variant-surface-glycoprotein inositol
-
 ?
3.1.4.50 membrane form of variant-surface-glycoprotein + H2O phospholipase D-type hydrolysis Homo sapiens phosphatidic acid + variant-surface-glycoprotein inositol
-
 ?
3.1.4.50 membrane form of variant-surface-glycoprotein + H2O phospholipase D-type hydrolysis Bos taurus phosphatidic acid + variant-surface-glycoprotein inositol
-
 ?
3.1.4.50 membrane form of variant-surface-glycoprotein + H2O phospholipase D-type hydrolysis Canis lupus familiaris phosphatidic acid + variant-surface-glycoprotein inositol
-
 ?
3.1.4.50 membrane form of variant-surface-glycoprotein + H2O phospholipase D-type hydrolysis Equus caballus phosphatidic acid + variant-surface-glycoprotein inositol
-
 ?
3.1.4.50 membrane form of variant-surface-glycoprotein + H2O phospholipase D-type hydrolysis Rattus norvegicus phosphatidic acid + variant-surface-glycoprotein inositol dimyristoylphosphatidic acid ?
3.1.4.50 membrane form of variant-surface-glycoprotein + H2O phospholipase D-type hydrolysis Oryctolagus cuniculus phosphatidic acid + variant-surface-glycoprotein inositol dimyristoylphosphatidic acid ?
3.1.4.50 additional information little or no activity towards phosphatidylinositol or phosphatidylcholine Rattus norvegicus ?
-
 ?
3.1.4.50 additional information little or no activity towards phosphatidylinositol or phosphatidylcholine Oryctolagus cuniculus ?
-
 ?