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Literature summary extracted from

  • Norris, F.A.; Atkins, R.C.; Majerus, P.W.
    The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family (1997), J. Biol. Chem., 272, 23859-23864.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.66 Inositol hexakisphosphate 50% inhibition at 0.05 mM Homo sapiens
3.1.3.66 Inositol hexakisphosphate 50% inhibition at 0.05 mM Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.66 0.028
-
 D-myo-Inositol 3,4-bisphosphate
-
 Homo sapiens
3.1.3.66 0.034
-
 D-myo-Inositol 1,3,4-trisphosphate
-
 Rattus norvegicus
3.1.3.66 0.039
-
 D-myo-Inositol 3,4-bisphosphate
-
 Rattus norvegicus
3.1.3.66 0.046
-
 D-myo-Inositol 1,3,4-trisphosphate
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.66 Homo sapiens Q96PE3 inositol polyphosphate 4-phosphatase type II
-
3.1.3.66 Rattus norvegicus Q9QWG5 inositol polyphosphate 4-phosphatase type II
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.66 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O
-
 Homo sapiens 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate
-
 ?
3.1.3.66 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + H2O
-
 Rattus norvegicus 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate
-
 ?
3.1.3.66 D-myo-inositol 1,3,4-trisphosphate + H2O
-
 Homo sapiens D-myo-inositol 3,4-bisphosphate + phosphate
-
 ?
3.1.3.66 D-myo-inositol 1,3,4-trisphosphate + H2O
-
 Rattus norvegicus D-myo-inositol 3,4-bisphosphate + phosphate
-
 ?
3.1.3.66 D-myo-inositol 3,4-bisphosphate + H2O
-
 Homo sapiens D-myo-inositol 4-phosphate + phosphate
-
 ?
3.1.3.66 D-myo-inositol 3,4-bisphosphate + H2O
-
 Rattus norvegicus D-myo-inositol 4-phosphate + phosphate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.66 7 8
-
 Homo sapiens
3.1.3.66 7 8
-
 Rattus norvegicus