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Literature summary extracted from

  • Höer, A.; Höer, D.; Oberdisse, E.
    Properties of a soluble inositol 1,3,4,5-tetrakisphosphate 3-phosphatase from porcine brain (1990), Biochem. J., 270, 715-719.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.62 ATP weak Sus scrofa
3.1.3.62 CTP more effective inhibitor than GTP Sus scrofa
3.1.3.62 GTP marked inhibition Sus scrofa
3.1.3.62 Inositol 1,3,4,5,6-pentakisphosphate
-
 Sus scrofa
3.1.3.62 inositol 1,3,4-trisphosphate mixed-type inhibition Sus scrofa
3.1.3.62 Inositol 1,4,5-trisphosphate product inhibition kinetics Sus scrofa
3.1.3.62 inositol 3,4,5,6-tetrakisphosphate commercially available with 12% inositol 2,4,5,6-tetrakisphosphate, from turkey erythrocytes, marked inhibition, linear mixed-type inhibition Sus scrofa
3.1.3.62 additional information not inhibited by Mg2+, Ca2+, Li+, non-hydrolysable adenine, guanine nucleotides or deoxynucleotides Sus scrofa
3.1.3.62 UTP more effective inhibitor than GTP Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.62 0.0004
-
 D-myo-Inositol 1,3,4,5-tetrakisphosphate
-
 Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.62 soluble
-
 Sus scrofa
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.62 KCl activation Sus scrofa
3.1.3.62 additional information not activated by Ca2+ up to 1 mM or Mg2+ up to 30 mM Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.3.62 36000
-
 gel filtration Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.62 D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O Sus scrofa enzyme may be regulated by the intracellular concentrations of inositol tris- and tetrakisphosphates D-myo-inositol 1,4,5-trisphosphate + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.62 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.3.62 partial Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.62 brain
-
 Sus scrofa
-

Storage Stability

EC Number Storage Stability Organism
3.1.3.62 -80°C, several months, stable Sus scrofa
3.1.3.62 4°C, within weeks, loss of activity Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.62 D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
-
 Sus scrofa D-myo-inositol 1,4,5-trisphosphate + phosphate
-
 ?
3.1.3.62 D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O enzyme may be regulated by the intracellular concentrations of inositol tris- and tetrakisphosphates Sus scrofa D-myo-inositol 1,4,5-trisphosphate + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.62 More may be identical with EC 3.1.3.65 Sus scrofa

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.3.62 37
-
 assay at Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.62 7.4
-
 assay at Sus scrofa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.3.62 0.0005
-
 inositol 3,4,5,6-tetrakisphosphate pH 7.4, 37°C Sus scrofa
3.1.3.62 0.00175
-
 inositol 1,3,4-trisphosphate pH 7.4, 37°C Sus scrofa
3.1.3.62 0.002
-
 Inositol 1,4,5-trisphosphate pH 7.4, 37°C Sus scrofa