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Literature summary extracted from

  • Hunt, M.; Lindquist, P.J.G.; Nousiainen, S.; Svensson, T.L.T.; Diczfalusy, U.; Alexson, S.E.H.
    Cloning and regulation of peroxisome proliferator-induced acyl-CoA thioesterases from mouse liver (1999), Adv. Exp. Med. Biol., 466, 195-200.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.2.2 Clofibrate peroxisome proliferator Mus musculus
3.1.2.2 Clofibrate isozymes CTE-I and MTE-I are induced, induction is completely dependent on PPARalpha Mus musculus
3.1.2.2 di(2-ethylhexyl)phthalate peroxisome proliferator Mus musculus
3.1.2.2 di(2-ethylhexyl)phthalate induction of enzyme expression Mus musculus
3.1.2.20 Clofibrate peroxisome proliferator Mus musculus
3.1.2.20 Clofibrate isozymes CTE-I and MTE-I are induced, induction is completely dependent on PPARalpha Mus musculus
3.1.2.20 di(2-ethylhexyl)phthalate peroxisome proliferator Mus musculus
3.1.2.20 di(2-ethylhexyl)phthalate induction of enzyme expression Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.2.2 isozymes CTE-I and MTE-I, DNA sequence and promotor analysis Mus musculus
3.1.2.20 isozymes CTE-I and MTE-I, DNA sequence and promotor analysis Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.2.2 cytosol isozyme CTE I Mus musculus 5829
-
3.1.2.2 mitochondrion isozyme MTE I Mus musculus 5739
-
3.1.2.20 cytosol isozyme CTE I Mus musculus 5829
-
3.1.2.20 mitochondrion isozyme MTE I Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.2.2 additional information Mus musculus enzyme regulation by dietary manipulation ?
-
 ?
3.1.2.20 additional information Mus musculus enzyme regulation by dietary manipulation ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.2 Mus musculus
-
 isozymes: cytosolic CTE-I, mitochondrial MTE-I
-
3.1.2.20 Mus musculus
-
 isozymes: cytosolic CTE-I, mitochondrial MTE-I
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.2.2 brain expression of isozyme CTE-I, not MTE-I Mus musculus
-
3.1.2.2 brown adipose tissue expression of isozyme CTE-I and MTE-I Mus musculus
-
3.1.2.2 heart expression of isozyme CTE-I and MTE-I Mus musculus
-
3.1.2.2 kidney isozymes CTE-I and MTE-I expression Mus musculus
-
3.1.2.2 liver isozyme CTE-I expression, low amount of isozyme MTE-I Mus musculus
-
3.1.2.2 muscle low expression of isozyme MTE-I Mus musculus
-
3.1.2.2 testis expression of isozyme CTE-I, not MTE-I Mus musculus
-
3.1.2.2 white adipose tissue expression of isozyme CTE-I and MTE-I Mus musculus
-
3.1.2.20 brain expression of isozyme CTE-I, not MTE-I Mus musculus
-
3.1.2.20 brown adipose tissue expression of isozyme CTE-I and MTE-I Mus musculus
-
3.1.2.20 heart expression of isozyme CTE-I and MTE-I Mus musculus
-
3.1.2.20 kidney isozymes CTE-I and MTE-I expression Mus musculus
-
3.1.2.20 liver isozyme CTE-I expression, low amount of isozyme MTE-I Mus musculus
-
3.1.2.20 muscle low expression of isozyme MTE-I Mus musculus
-
3.1.2.20 testis expression of isozyme CTE-I, not MTE-I Mus musculus
-
3.1.2.20 white adipose tissue expression of isozyme CTE-I and MTE-I Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.2 acyl-CoA + H2O
-
 Mus musculus CoA + a carboxylate
-
 ?
3.1.2.2 additional information enzyme regulation by dietary manipulation Mus musculus ?
-
 ?
3.1.2.20 acyl-CoA + H2O
-
 Mus musculus CoA + a carboxylate
-
 ?
3.1.2.20 additional information enzyme regulation by dietary manipulation Mus musculus ?
-
 ?