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Literature summary extracted from

  • Yamada, J.; Furihata, T.; Tamura, H.; Watanabe, T.; Suga, T.
    Long-chain acyl-CoA hydrolase from rat brain cytosol: purification, characterization, and immunohistochemical localization (1996), Arch. Biochem. Biophys., 326, 106-114.
    View publication on PubMed

General Stability

EC Number General Stability Organism
3.1.2.2 20% ethylene glycol or 0.001mM ammonium sulfate overcomes cold lability Rattus norvegicus
3.1.2.20 20% ethylene glycol or 0.001mM ammonium sulfate overcomes cold lability Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.2.2 Ca2+
-
 Bos taurus
3.1.2.2 Ca2+
-
 Oryctolagus cuniculus
3.1.2.2 Ca2+
-
 Rattus norvegicus
3.1.2.2 Mg2+
-
 Bos taurus
3.1.2.2 Mg2+
-
 Rattus norvegicus
3.1.2.2 Mn2+
-
 Bos taurus
3.1.2.2 Mn2+
-
 Rattus norvegicus
3.1.2.2 Mn2+
-
 Sus scrofa
3.1.2.2 p-chloromercuribenzoic acid
-
 Rattus norvegicus
3.1.2.20 Ca2+
-
 Bos taurus
3.1.2.20 Ca2+
-
 Oryctolagus cuniculus
3.1.2.20 Ca2+
-
 Rattus norvegicus
3.1.2.20 Mg2+
-
 Bos taurus
3.1.2.20 Mg2+
-
 Rattus norvegicus
3.1.2.20 Mn2+
-
 Bos taurus
3.1.2.20 Mn2+
-
 Rattus norvegicus
3.1.2.20 Mn2+
-
 Sus scrofa
3.1.2.20 p-chloromercuribenzoic acid
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.2.2 0.0057
-
 hexadecanoyl-CoA
-
 Rattus norvegicus
3.1.2.20 0.0057
-
 hexadecanoyl-CoA
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.2.2 cytosol
-
 Homo sapiens 5829
-
3.1.2.2 cytosol
-
 Rattus norvegicus 5829
-
3.1.2.2 cytosol
-
 Sus scrofa 5829
-
3.1.2.2 cytosol
-
 Oryctolagus cuniculus 5829
-
3.1.2.20 cytosol
-
 Homo sapiens 5829
-
3.1.2.20 cytosol
-
 Rattus norvegicus 5829
-
3.1.2.20 cytosol
-
 Sus scrofa 5829
-
3.1.2.20 cytosol
-
 Oryctolagus cuniculus 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.2.2 36000
-
 3 * 36000, SDs-PAGE Rattus norvegicus
3.1.2.2 104000
-
 gel filtration Rattus norvegicus
3.1.2.20 36000
-
 3 * 36000, SDs-PAGE Rattus norvegicus
3.1.2.20 104000
-
 gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.2.2 palmitoyl-CoA + H2O Cavia porcellus
-
 CoA + palmitate
-
 ?
3.1.2.2 palmitoyl-CoA + H2O Homo sapiens
-
 CoA + palmitate
-
 ?
3.1.2.2 palmitoyl-CoA + H2O Rattus norvegicus
-
 CoA + palmitate
-
 ?
3.1.2.2 palmitoyl-CoA + H2O Sus scrofa
-
 CoA + palmitate
-
 ?
3.1.2.2 palmitoyl-CoA + H2O Oryctolagus cuniculus
-
 CoA + palmitate
-
 ?
3.1.2.2 palmitoyl-CoA + H2O Canis lupus familiaris
-
 CoA + palmitate
-
 ?
3.1.2.2 palmitoyl-CoA + H2O Mesocricetus auratus
-
 CoA + palmitate
-
 ?
3.1.2.2 palmitoyl-CoA + H2O Platyrrhini
-
 CoA + palmitate
-
 ?
3.1.2.20 palmitoyl-CoA + H2O Cavia porcellus
-
 CoA + palmitate
-
 ?
3.1.2.20 palmitoyl-CoA + H2O Homo sapiens
-
 CoA + palmitate
-
 ?
3.1.2.20 palmitoyl-CoA + H2O Rattus norvegicus
-
 CoA + palmitate
-
 ?
3.1.2.20 palmitoyl-CoA + H2O Sus scrofa
-
 CoA + palmitate
-
 ?
3.1.2.20 palmitoyl-CoA + H2O Oryctolagus cuniculus
-
 CoA + palmitate
-
 ?
3.1.2.20 palmitoyl-CoA + H2O Canis lupus familiaris
-
 CoA + palmitate
-
 ?
3.1.2.20 palmitoyl-CoA + H2O Mesocricetus auratus
-
 CoA + palmitate
-
 ?
3.1.2.20 palmitoyl-CoA + H2O Platyrrhini
-
 CoA + palmitate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.2 Bos taurus
-
-
-
3.1.2.2 Canis lupus familiaris
-
 beagle
-
3.1.2.2 Cavia porcellus
-
 albino Hartley guinea pig
-
3.1.2.2 Homo sapiens
-
-
-
3.1.2.2 Mesocricetus auratus
-
-
-
3.1.2.2 Oryctolagus cuniculus
-
 Japanese white rabbit
-
3.1.2.2 Platyrrhini
-
 crab eating
-
3.1.2.2 Rattus norvegicus
-
 Wistar rats
-
3.1.2.2 Sus scrofa
-
-
-
3.1.2.20 Bos taurus
-
-
-
3.1.2.20 Canis lupus familiaris
-
 beagle
-
3.1.2.20 Cavia porcellus
-
 albino Hartley guinea pig
-
3.1.2.20 Homo sapiens
-
-
-
3.1.2.20 Mesocricetus auratus
-
-
-
3.1.2.20 Oryctolagus cuniculus
-
 Japanese white rabbit
-
3.1.2.20 Platyrrhini
-
 crab eating
-
3.1.2.20 Rattus norvegicus
-
 Wistar rats
-
3.1.2.20 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.2.2 680fold Rattus norvegicus
3.1.2.20 680fold Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.2.2 brain
-
 Cavia porcellus
-
3.1.2.2 brain
-
 Homo sapiens
-
3.1.2.2 brain
-
 Rattus norvegicus
-
3.1.2.2 brain
-
 Sus scrofa
-
3.1.2.2 brain
-
 Bos taurus
-
3.1.2.2 brain
-
 Oryctolagus cuniculus
-
3.1.2.2 brain
-
 Canis lupus familiaris
-
3.1.2.2 brain
-
 Mesocricetus auratus
-
3.1.2.2 brain
-
 Platyrrhini
-
3.1.2.2 cerebellum
-
 Rattus norvegicus
-
3.1.2.2 cerebral cortex
-
 Cavia porcellus
-
3.1.2.2 cerebral cortex
-
 Rattus norvegicus
-
3.1.2.2 corpus striatum
-
 Rattus norvegicus
-
3.1.2.2 hippocampus
-
 Rattus norvegicus
-
3.1.2.2 medulla oblongata
-
 Rattus norvegicus
-
3.1.2.2 additional information
-
 Rattus norvegicus
-
3.1.2.2 neuron
-
 Rattus norvegicus
-
3.1.2.2 olfactory bulb
-
 Rattus norvegicus
-
3.1.2.2 pons
-
 Rattus norvegicus
-
3.1.2.2 spinal cord
-
 Rattus norvegicus
-
3.1.2.20 brain
-
 Cavia porcellus
-
3.1.2.20 brain
-
 Homo sapiens
-
3.1.2.20 brain
-
 Rattus norvegicus
-
3.1.2.20 brain
-
 Sus scrofa
-
3.1.2.20 brain
-
 Bos taurus
-
3.1.2.20 brain
-
 Oryctolagus cuniculus
-
3.1.2.20 brain
-
 Canis lupus familiaris
-
3.1.2.20 brain
-
 Mesocricetus auratus
-
3.1.2.20 brain
-
 Platyrrhini
-
3.1.2.20 cerebellum
-
 Rattus norvegicus
-
3.1.2.20 cerebral cortex
-
 Cavia porcellus
-
3.1.2.20 cerebral cortex
-
 Rattus norvegicus
-
3.1.2.20 corpus striatum
-
 Rattus norvegicus
-
3.1.2.20 hippocampus
-
 Rattus norvegicus
-
3.1.2.20 medulla oblongata
-
 Rattus norvegicus
-
3.1.2.20 additional information
-
 Rattus norvegicus
-
3.1.2.20 neuron
-
 Rattus norvegicus
-
3.1.2.20 olfactory bulb
-
 Rattus norvegicus
-
3.1.2.20 pons
-
 Rattus norvegicus
-
3.1.2.20 spinal cord
-
 Rattus norvegicus
-

Storage Stability

EC Number Storage Stability Organism
3.1.2.2 stable at 25°C over 24 h Rattus norvegicus
3.1.2.20 stable at 25°C over 24 h Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.2 hexadecanoyl-CoA + H2O i.e. palmitoyl-CoA Cavia porcellus CoA + hexadecanoate
-
 ?
3.1.2.2 hexadecanoyl-CoA + H2O i.e. palmitoyl-CoA Homo sapiens CoA + hexadecanoate
-
 ?
3.1.2.2 hexadecanoyl-CoA + H2O i.e. palmitoyl-CoA Rattus norvegicus CoA + hexadecanoate
-
 ?
3.1.2.2 hexadecanoyl-CoA + H2O i.e. palmitoyl-CoA Sus scrofa CoA + hexadecanoate
-
 ?
3.1.2.2 hexadecanoyl-CoA + H2O i.e. palmitoyl-CoA Oryctolagus cuniculus CoA + hexadecanoate
-
 ?
3.1.2.2 hexadecanoyl-CoA + H2O i.e. palmitoyl-CoA Mesocricetus auratus CoA + hexadecanoate
-
 ?
3.1.2.2 hexadecanoyl-CoA + H2O i.e. palmitoyl-CoA Platyrrhini CoA + hexadecanoate
-
 ?
3.1.2.2 octadecanoyl-CoA + H2O i.e. stearoyl-CoA Rattus norvegicus CoA + octadecanoate
-
 ?
3.1.2.2 oleoyl-CoA + H2O
-
 Cavia porcellus CoA + oleate
-
 ?
3.1.2.2 oleoyl-CoA + H2O
-
 Homo sapiens CoA + oleate
-
 ?
3.1.2.2 oleoyl-CoA + H2O
-
 Rattus norvegicus CoA + oleate
-
 ?
3.1.2.2 oleoyl-CoA + H2O
-
 Sus scrofa CoA + oleate
-
 ?
3.1.2.2 oleoyl-CoA + H2O
-
 Bos taurus CoA + oleate
-
 ?
3.1.2.2 oleoyl-CoA + H2O
-
 Oryctolagus cuniculus CoA + oleate
-
 ?
3.1.2.2 palmitoyl-CoA + H2O
-
 Cavia porcellus CoA + palmitate
-
 ?
3.1.2.2 palmitoyl-CoA + H2O
-
 Homo sapiens CoA + palmitate
-
 ?
3.1.2.2 palmitoyl-CoA + H2O
-
 Rattus norvegicus CoA + palmitate
-
 ?
3.1.2.2 palmitoyl-CoA + H2O
-
 Sus scrofa CoA + palmitate
-
 ?
3.1.2.2 palmitoyl-CoA + H2O
-
 Oryctolagus cuniculus CoA + palmitate
-
 ?
3.1.2.2 palmitoyl-CoA + H2O
-
 Canis lupus familiaris CoA + palmitate
-
 ?
3.1.2.2 palmitoyl-CoA + H2O
-
 Mesocricetus auratus CoA + palmitate
-
 ?
3.1.2.2 palmitoyl-CoA + H2O
-
 Platyrrhini CoA + palmitate
-
 ?
3.1.2.20 hexadecanoyl-CoA + H2O i.e. palmitoyl-CoA Cavia porcellus CoA + hexadecanoate
-
 ?
3.1.2.20 hexadecanoyl-CoA + H2O i.e. palmitoyl-CoA Homo sapiens CoA + hexadecanoate
-
 ?
3.1.2.20 hexadecanoyl-CoA + H2O i.e. palmitoyl-CoA Rattus norvegicus CoA + hexadecanoate
-
 ?
3.1.2.20 hexadecanoyl-CoA + H2O i.e. palmitoyl-CoA Sus scrofa CoA + hexadecanoate
-
 ?
3.1.2.20 hexadecanoyl-CoA + H2O i.e. palmitoyl-CoA Oryctolagus cuniculus CoA + hexadecanoate
-
 ?
3.1.2.20 hexadecanoyl-CoA + H2O i.e. palmitoyl-CoA Mesocricetus auratus CoA + hexadecanoate
-
 ?
3.1.2.20 hexadecanoyl-CoA + H2O i.e. palmitoyl-CoA Platyrrhini CoA + hexadecanoate
-
 ?
3.1.2.20 octadecanoyl-CoA + H2O i.e. stearoyl-CoA Rattus norvegicus CoA + octadecanoate
-
 ?
3.1.2.20 oleoyl-CoA + H2O
-
 Cavia porcellus CoA + oleate
-
 ?
3.1.2.20 oleoyl-CoA + H2O
-
 Homo sapiens CoA + oleate
-
 ?
3.1.2.20 oleoyl-CoA + H2O
-
 Rattus norvegicus CoA + oleate
-
 ?
3.1.2.20 oleoyl-CoA + H2O
-
 Sus scrofa CoA + oleate
-
 ?
3.1.2.20 oleoyl-CoA + H2O
-
 Bos taurus CoA + oleate
-
 ?
3.1.2.20 oleoyl-CoA + H2O
-
 Oryctolagus cuniculus CoA + oleate
-
 ?
3.1.2.20 palmitoyl-CoA + H2O
-
 Cavia porcellus CoA + palmitate
-
 ?
3.1.2.20 palmitoyl-CoA + H2O
-
 Homo sapiens CoA + palmitate
-
 ?
3.1.2.20 palmitoyl-CoA + H2O
-
 Rattus norvegicus CoA + palmitate
-
 ?
3.1.2.20 palmitoyl-CoA + H2O
-
 Sus scrofa CoA + palmitate
-
 ?
3.1.2.20 palmitoyl-CoA + H2O
-
 Oryctolagus cuniculus CoA + palmitate
-
 ?
3.1.2.20 palmitoyl-CoA + H2O
-
 Canis lupus familiaris CoA + palmitate
-
 ?
3.1.2.20 palmitoyl-CoA + H2O
-
 Mesocricetus auratus CoA + palmitate
-
 ?
3.1.2.20 palmitoyl-CoA + H2O
-
 Platyrrhini CoA + palmitate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.2.2 trimer 3 * 36000, SDs-PAGE Rattus norvegicus
3.1.2.20 trimer 3 * 36000, SDs-PAGE Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.2.2 30
-
-
 Rattus norvegicus
3.1.2.20 30
-
-
 Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.2.2 7.1 8.3
-
 Rattus norvegicus
3.1.2.20 7.1 8.3
-
 Rattus norvegicus