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Literature summary extracted from

  • Berge, R.K.; Farstad, M.
    Purification and characterization of long-chain acyl-CoA hydrolase from rat liver mitochondria (1979), Eur. J. Biochem., 96, 393-401.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.2.2 Triton X-100 prevents inhibition together with serum albumin Rattus norvegicus
3.1.2.20 Triton X-100 prevents inhibition together with serum albumin Rattus norvegicus

General Stability

EC Number General Stability Organism
3.1.2.2 bovine serum albumin stabilizes Rattus norvegicus
3.1.2.2 glycerol and palmitoyl-CoA stabilize Rattus norvegicus
3.1.2.20 bovine serum albumin stabilizes Rattus norvegicus
3.1.2.20 glycerol and palmitoyl-CoA stabilize Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.2.2 Mn2+
-
 Rattus norvegicus
3.1.2.2 sodium deoxycholate
-
 Rattus norvegicus
3.1.2.20 Mn2+
-
 Rattus norvegicus
3.1.2.20 sodium deoxycholate
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.2.2 0.0008
-
 hexadecanoyl-CoA
-
 Rattus norvegicus
3.1.2.20 0.0008
-
 hexadecanoyl-CoA
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.2.2 mitochondrion
-
 Rattus norvegicus 5739
-
3.1.2.20 mitochondrion
-
 Rattus norvegicus 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.2.2 19000
-
 gel filtration Rattus norvegicus
3.1.2.20 19000
-
 gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.2.2 palmitoyl-CoA + H2O Rattus norvegicus
-
 CoA + palmitate
-
 ?
3.1.2.20 palmitoyl-CoA + H2O Rattus norvegicus
-
 CoA + palmitate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.2 Rattus norvegicus
-
-
-
3.1.2.20 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.2.2 52.6fold Rattus norvegicus
3.1.2.20 52.6fold Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.2.2 liver
-
 Rattus norvegicus
-
3.1.2.20 liver
-
 Rattus norvegicus
-

Storage Stability

EC Number Storage Stability Organism
3.1.2.2 -20°C over 1 month Rattus norvegicus
3.1.2.20 -20°C over 1 month Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.2 acyl-CoA + H2O long-chain fatty-acyl-CoA Rattus norvegicus CoA + a carboxylate
-
 ?
3.1.2.2 decanoyl-CoA + H2O
-
 Rattus norvegicus CoA + decanoate
-
 ?
3.1.2.2 dodecanoyl-CoA + H2O i.e. lauroyl-CoA Rattus norvegicus CoA + dodecanoate
-
 ?
3.1.2.2 hexadecanoyl-CoA + H2O i.e. palmitoyl-CoA Rattus norvegicus CoA + hexadecanoate
-
 ?
3.1.2.2 octadecanoyl-CoA + H2O i.e. stearoyl-CoA Rattus norvegicus CoA + octadecanoate
-
 ?
3.1.2.2 oleoyl-CoA + H2O
-
 Rattus norvegicus CoA + oleate
-
 ?
3.1.2.2 palmitoyl-CoA + H2O
-
 Rattus norvegicus CoA + palmitate
-
 ?
3.1.2.2 tetradecanoyl-CoA + H2O i.e. myristoyl-CoA Rattus norvegicus CoA + tetradecanoate
-
 ?
3.1.2.20 acyl-CoA + H2O long-chain fatty-acyl-CoA Rattus norvegicus CoA + a carboxylate
-
 ?
3.1.2.20 decanoyl-CoA + H2O
-
 Rattus norvegicus CoA + decanoate
-
 ?
3.1.2.20 dodecanoyl-CoA + H2O i.e. lauroyl-CoA Rattus norvegicus CoA + dodecanoate
-
 ?
3.1.2.20 hexadecanoyl-CoA + H2O i.e. palmitoyl-CoA Rattus norvegicus CoA + hexadecanoate
-
 ?
3.1.2.20 octadecanoyl-CoA + H2O i.e. stearoyl-CoA Rattus norvegicus CoA + octadecanoate
-
 ?
3.1.2.20 oleoyl-CoA + H2O
-
 Rattus norvegicus CoA + oleate
-
 ?
3.1.2.20 palmitoyl-CoA + H2O
-
 Rattus norvegicus CoA + palmitate
-
 ?
3.1.2.20 tetradecanoyl-CoA + H2O i.e. myristoyl-CoA Rattus norvegicus CoA + tetradecanoate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.2.2 8 8.5
-
 Rattus norvegicus
3.1.2.20 8 8.5
-
 Rattus norvegicus