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Literature summary extracted from

  • Fenselau, A.; Wallis, K.
    Comparative studies on 3-oxo acid coenzyme A transferase from various rat tissues (1974), Biochem. J., 142, 619-627.
    View publication on PubMedView publication on EuropePMC

General Stability

EC Number General Stability Organism
2.8.3.5 deoxycholate does not stabilize Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.3.5 succinate product inhibition Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.3.5 0.2
-
 acetoacetate heart, succinyl CoA as second substrate Rattus norvegicus
2.8.3.5 0.21
-
 acetoacetate kidney, skeletal muscle, pH 8.1, 25°C Rattus norvegicus
2.8.3.5 0.31
-
 acetoacetate brain, pH 8.1, 25°C Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.3.5 mitochondrion predominantly Rattus norvegicus 5739
-
2.8.3.5 additional information subcellular distribution Rattus norvegicus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.8.3.5 100000
-
 gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.3.5 succinyl-CoA + acetoacetate Rattus norvegicus ketolytic enzyme, uniquely involved in complete oxidation of ketone bodies ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.3.5 Rattus norvegicus
-
 male adult Buffalo
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.8.3.5 homogeneity Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.3.5 brain
-
 Rattus norvegicus
-
2.8.3.5 kidney
-
 Rattus norvegicus
-
2.8.3.5 liver
-
 Rattus norvegicus
-
2.8.3.5 skeletal muscle
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.3.5 succinyl-CoA + acetoacetate
-
 Rattus norvegicus succinate + acetoacetyl-CoA
-
 r
2.8.3.5 succinyl-CoA + acetoacetate ketolytic enzyme, uniquely involved in complete oxidation of ketone bodies Rattus norvegicus ?
-
 ?

pI Value

EC Number Organism Comment pI Value Maximum pI Value
2.8.3.5 Rattus norvegicus heart enzyme, pH gradient 7-9
-
 6.8
2.8.3.5 Rattus norvegicus kidney, brain, muscle and liver enzyme, pH gradient 7-9
-
 7.6