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Literature summary extracted from

  • Moore, K.L.
    The biology and enzymology of protein tyrosine O-sulfation (2003), J. Biol. Chem., 278, 24243-24246.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.2.20 Golgi apparatus
-
 Mammalia 5794
-
2.8.2.20 Golgi apparatus
-
 Drosophila melanogaster 5794
-

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.20 Drosophila melanogaster Q9VYB7 only 1 isoform
-
2.8.2.20 Homo sapiens
-
-
-
2.8.2.20 Mammalia
-
 isoforms TPST1 and TPST2
-
2.8.2.20 no activity in prokaryotes
-
-
-
2.8.2.20 no activity in yeast
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.20 3'-phosphoadenylylsulfate + acidic polypeptide tyrosine
-
 Homo sapiens adenosine 3',5'-bisphosphate + acidic polypeptide tyrosine-O-sulfate
-
 ?
2.8.2.20 3'-phosphoadenylylsulfate + acidic polypeptide tyrosine dominant characteristic is that there are generally between 3 and 4 acidic amino acids within the +/-5 residues of the sulfotyrosine Drosophila melanogaster adenosine 3',5'-bisphosphate + acidic polypeptide tyrosine-O-sulfate
-
 ?
2.8.2.20 3'-phosphoadenylylsulfate + acidic polypeptide tyrosine dominant characteristic is that there are generally between 3 and 4 acidic amino acids within the +/-5 residues of the sulfotyrosine Mammalia adenosine 3',5'-bisphosphate + acidic polypeptide tyrosine-O-sulfate
-
 ?
2.8.2.20 3'-phosphoadenylylsulfate + C4 alpha chain more efficiently sulphated by TPST1 than TPST2 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.20 3'-phosphoadenylylsulfate + heparin cofactor II more efficiently sulphated by TPST1 than TPST2 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?