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Literature summary extracted from

  • Singer, S.S.; Brill, B.
    Enzymatic sulfation of steroids. XVII. The properties of the glucocorticoid sulfotransferase activity of guinea pig liver cytosol (1982), Biochim. Biophys. Acta, 712, 590-596.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.2.18 0.06 0.087 cortisol pH 6.8, 37.5°C Cavia porcellus
2.8.2.18 0.15 0.188 3'-phosphoadenylylsulfate pH 6.8, 37.5°C Cavia porcellus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.2.18 cytosol
-
 Cavia porcellus 5829
-
2.8.2.18 cytosol
-
 Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.18 3'-phosphoadenylylsulfate + cortisol Cavia porcellus
-
 adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
 ?
2.8.2.18 3'-phosphoadenylylsulfate + cortisol Rattus norvegicus
-
 adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
 ?
2.8.2.18 3'-phosphoadenylylsulfate + cortisol Cavia porcellus Hartley
-
 adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.18 Cavia porcellus
-
 guinea pig, male and female albinos, Hartley strain
-
2.8.2.18 Cavia porcellus Hartley
-
 guinea pig, male and female albinos, Hartley strain
-
2.8.2.18 Rattus norvegicus
-
 female Sprague-Dawley CD rats
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.8.2.18 partial Cavia porcellus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.18 liver
-
 Cavia porcellus
-
2.8.2.18 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.18 3'-phosphoadenylylsulfate + cortisol
-
 Cavia porcellus adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
 ?
2.8.2.18 3'-phosphoadenylylsulfate + cortisol
-
 Rattus norvegicus adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
 ?
2.8.2.18 3'-phosphoadenylylsulfate + cortisol no substrates are AMP, ADP, ATP or GTP Cavia porcellus adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
 ?
2.8.2.18 3'-phosphoadenylylsulfate + cortisol
-
 Cavia porcellus Hartley adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
 ?
2.8.2.18 3'-phosphoadenylylsulfate + cortisol no substrates are AMP, ADP, ATP or GTP Cavia porcellus Hartley adenosine 3',5'-bisphosphate + cortisol 21-sulfate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.8.2.18 37.5
-
 assay at Cavia porcellus
2.8.2.18 37.5
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.8.2.18 6.7 6.9
-
 Cavia porcellus