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Literature summary extracted from

  • Ollagnier-de-Choudens, S.; Mulliez, E.; Fontecave, M.
    The PLP-dependent biotin synthase from Escherichia coli: mechanistic studies (2002), FEBS Lett., 532, 465-468.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.8.1.6 S-adenosyl-L-methionine one molecule S-adenosyl-L-methionine is required to form one molecule of biotin Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.1.6 5'-deoxyadenosine strong inhibitor, reversible, 90% inhibition upon addition of 1 equivalent of 5'-deoxyadenosine with regard to the enzyme Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.8.1.6 Iron the enzyme contains an iron-sulfur cluster Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.1.6 dethiobiotin + sulfur Escherichia coli catalyzes the last step of the biosynthesis of biotin biotin
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.8.1.6 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.1.6 dethiobiotin + sulfur
-
Escherichia coli biotin
-
?
2.8.1.6 dethiobiotin + sulfur catalyzes the last step of the biosynthesis of biotin Escherichia coli biotin
-
?