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Literature summary extracted from

  • Sribney, M.; Kennedy, E.P.
    The enzymatic synthesis of sphingomyelin (1958), J. Biol. Chem., 233, 1315-1322.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.3 cytidine diphosphate choline + N-acyl-threo-trans-sphingosine Gallus gallus
-
CMP + sphingomyelin
-
?
2.7.8.3 cytidine diphosphate choline + N-acyl-threo-trans-sphingosine Rattus norvegicus
-
CMP + sphingomyelin
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.3 Cavia porcellus
-
guinea pig
-
2.7.8.3 Gallus gallus
-
chicken
-
2.7.8.3 Rattus norvegicus
-
rat
-
2.7.8.3 Sus scrofa
-
pig
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.8.3 brain
-
Rattus norvegicus
-
2.7.8.3 kidney
-
Rattus norvegicus
-
2.7.8.3 liver
-
Gallus gallus
-
2.7.8.3 liver
-
Cavia porcellus
-
2.7.8.3 liver
-
Rattus norvegicus
-
2.7.8.3 liver
-
Sus scrofa
-
2.7.8.3 spleen
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.3 cytidine diphosphate choline + ceramide
-
Gallus gallus CMP + sphingomyelin
-
?
2.7.8.3 cytidine diphosphate choline + ceramide
-
Rattus norvegicus CMP + sphingomyelin
-
?
2.7.8.3 cytidine diphosphate choline + N-acetyl-DL-threo-1,3-dihydroxy-2-amino-octadecyne
-
Gallus gallus CMP + sphingomyelin
-
?
2.7.8.3 cytidine diphosphate choline + N-acetyl-DL-threo-trans-sphingosine
-
Gallus gallus CMP + sphingomyelin
-
?
2.7.8.3 cytidine diphosphate choline + N-acetyl-DL-threo-trans-sphingosine
-
Rattus norvegicus CMP + sphingomyelin
-
?
2.7.8.3 cytidine diphosphate choline + N-acyl-threo-trans-sphingosine
-
Gallus gallus CMP + sphingomyelin
-
?
2.7.8.3 cytidine diphosphate choline + N-acyl-threo-trans-sphingosine
-
Rattus norvegicus CMP + sphingomyelin
-
?
2.7.8.3 cytidine diphosphate choline + N-octanoyl-DL-threo-1,3-dihydroxy-2-amino-octadecyne
-
Gallus gallus CMP + sphingomyelin
-
?
2.7.8.3 additional information highly specific for CDP-choline, little or no reaction with N-acetyl-DL-threo-dihydrosphingosine and N-acetylphytosphingosine, synthetically prepared UDP-choline, ADP-choline, and GDP-choline shows no detectable activity Gallus gallus ?
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.8.3 45
-
-
Gallus gallus

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
2.7.8.3 25 55 about 60% of activity maximum at 25°C, about 70% of activity maximum at 55°C Gallus gallus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.8.3 7.5 8
-
Gallus gallus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.7.8.3 7 8.5 about 50% of activity maximum at pH 7.0, about 45% of activity maximum at pH 8.5 Gallus gallus