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Literature summary extracted from
- Polyribitol phosphate synthetase of Staphylococcus aureus (1966), J. Biol. Chem., 241, 639-650.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.7.8.14 | CMP | - |
Staphylococcus aureus |  |
| 2.7.8.14 | Gentian violet | - |
Staphylococcus aureus | |
| 2.7.8.14 | additional information | no inhibition: penicillin G, staphcillin, alpha-aminobenzyl-penicillin, bacitracin | Staphylococcus aureus | |
| 2.7.8.14 | novobiocin | - |
Staphylococcus aureus | |
| 2.7.8.14 | Ristocetin | - |
Staphylococcus aureus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 2.7.8.14 | 0.1 | - |
CDPribitol | in presence of Mn2+ | Staphylococcus aureus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 2.7.8.14 | particle-bound | - |
Staphylococcus aureus | - |
- |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.7.8.14 | Co2+ | slight stimulation | Staphylococcus aureus | |
| 2.7.8.14 | Mg2+ | Mn2+ or Mg2+ required: 10-30 mM | Staphylococcus aureus | |
| 2.7.8.14 | Mn2+ | Mn2+ or Mg2+ required, optimal concentration: 10-30 mM | Staphylococcus aureus | |
| 2.7.8.14 | additional information | no effect: Ni2+, Zn2+, Ca2+ | Staphylococcus aureus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.7.8.14 | CDPribitol + (ribitol phosphate)n | Staphylococcus aureus | - |
CMP + (ribitol phosphate)n+1 | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.7.8.14 | Staphylococcus aureus | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.7.8.14 | CDPribitol + (ribitol phosphate)n | - |
Staphylococcus aureus | CMP + (ribitol phosphate)n+1 | - |
? | |
| 2.7.8.14 | CDPribitol + (ribitol phosphate)n | no substrate: D-ribitol 5-phosphate, CDP-ribitol treated with diphosphatase, acid or alkali | Staphylococcus aureus | CMP + (ribitol phosphate)n+1 | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 2.7.8.14 | 7.8 | - |
Tris-HCl buffer | Staphylococcus aureus |
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Release 2023.1 (January 2023)
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