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Literature summary extracted from

  • Wootton, J.A.; Kinsella, J.E.
    Properties of cytidinediphosphodiacyl-sn-glycerol:myoinositol transferase of bovine mammary tissue (1977), Int. J. Biochem., 8, 449-456.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.8.11 2-mercaptoethanol enhances enzyme activity Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.8.11 Ca2+ inhibition above 2 mM Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.8.11 0.06
-
 CDP-didecanoyl-sn-glycerol
-
 Bos taurus
2.7.8.11 0.71
-
 myo-inositol
-
 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.8.11 microsome
-
 Bos taurus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.8.11 Mg2+
-
 Bos taurus
2.7.8.11 Mn2+
-
 Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.11 CDP-diacylglycerol + myo-inositol Bos taurus enzyme catalyzes the final step of de novo synthesis of phosphatidylinositol CMP + phosphatidyl-1D-myo-inositol
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.11 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.8.11 mammary gland
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.8.11 0.002 0.009
-
 Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.11 CDP-diacylglycerol + myo-inositol
-
 Bos taurus CMP + phosphatidyl-1D-myo-inositol
-
 r
2.7.8.11 CDP-diacylglycerol + myo-inositol enzyme catalyzes the final step of de novo synthesis of phosphatidylinositol Bos taurus CMP + phosphatidyl-1D-myo-inositol
-
 r
2.7.8.11 CDP-diacylglycerol + myo-inositol
-
 Bos taurus CMP + 1-phosphatidyl-1D-myo-inositol
-
 ?
2.7.8.11 CDP-didecanoyl-sn-glycerol + myo-inositol preferred substrate Bos taurus CMP + didecanoylphosphatidylinositol
-
 r
2.7.8.11 CDP-dioleoylglycerol + myo-inositol
-
 Bos taurus CMP + dioleoylphosphatidylinositol
-
 r
2.7.8.11 CDP-dipalmitoyl-sn-glycerol + myo-inositol
-
 Bos taurus CMP + dipalmitoylphosphatidylinositol
-
 r

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.8.11 7.7
-
 CTP and phosphatidic acid as substrate Bos taurus
2.7.8.11 8.5 9 CDP-diacyl-sn-glycerol as substrate Bos taurus