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Literature summary extracted from

  • Tzeng, Y.L.; Datta, A.; Strole, C.; Kolli, V.S.; Birck, M.R.; Taylor, W.P.; Carlson, R.W.; Woodard, R.W.; Stephens, D.S.
    KpsF is the arabinose-5-phosphate isomerase required for 3-deoxy-D-manno-octulosonic acid biosynthesis and for both lipooligosaccharide assembly and capsular polysaccharide expression in Neisseria meningitidis (2002), J. Biol. Chem., 277, 24103-24113.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.7.38 medicine exclusive pathogen of humans, cause of epidemic bacterial meningitis and sepsis, potential target for develpoment of antibiotic tools Neisseria meningitidis

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.38 KpsF cloned in Escherichia coli DH5alpha, overexpressed in Escherichia coli BLR21(DE3)pLysS Neisseria meningitidis
5.3.1.13 expression in Escherichia coli Neisseria meningitidis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate Neisseria meningitidis
-
 diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
5.3.1.13 additional information Neisseria meningitidis enzyme is required for 3-deoxy-D-manno-octulosonic acid biosynthesis and for both lipooligosaccharide assembly and capsular polysaccharide expression ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.38 Neisseria meningitidis
-
-
-
5.3.1.13 Neisseria meningitidis
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.7.38 recombinant protein, expressed in Escherichia coli Neisseria meningitidis
5.3.1.13
-
 Neisseria meningitidis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.38 CTP + 3-deoxy-D-manno-octulosonate
-
 Neisseria meningitidis diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
 r
5.3.1.13 additional information enzyme is required for 3-deoxy-D-manno-octulosonic acid biosynthesis and for both lipooligosaccharide assembly and capsular polysaccharide expression Neisseria meningitidis ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.38 arabinose-5-phosphate isomerase required for 3-deoxy-D-manno-octulosonic acid biosynthesis and for both lipooligosaccharide assembly and capsular polysaccharide expression Neisseria meningitidis
2.7.7.38 KpsF
-
 Neisseria meningitidis
5.3.1.13 KpsF
-
 Neisseria meningitidis