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Literature summary extracted from

  • Lee, L.S.; Cheng, Y.C.
    Human thymidylate kinase. Purification, characterization, and kinetic behavior of the thymidylate kinase derived from chronic myelocytic leukemia (1977), J. Biol. Chem., 252, 5686-5691.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.4.9 ADP
-
 Homo sapiens
2.7.4.9 dADP
-
 Homo sapiens
2.7.4.9 dTDP
-
 Homo sapiens
2.7.4.9 dTTP
-
 Homo sapiens
2.7.4.9 thymidine 0.77 mM, 27% inhibition Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.4.9 0.13
-
 dATP pH 7.2, 37°C Homo sapiens
2.7.4.9 0.25
-
 ATP pH 7.2, 37°C Homo sapiens
2.7.4.9 0.33
-
 GTP pH 7.2, 37°C Homo sapiens
2.7.4.9 0.45
-
 dGTP pH 7.2, 37°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.9 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.4.9
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.4.9 blast cell of chronic myelocytic leukemia Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.4.9 0.809
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.9 dATP + dTMP dATP is as active as ATP Homo sapiens dADP + dTDP
-
 ?
2.7.4.9 dGTP + dTMP 42% of the activity with ATP Homo sapiens dGDP + dTDP
-
 ?
2.7.4.9 GTP + dTMP 38% of maximal activity Homo sapiens GDP + dTDP
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.4.9 0.75
-
 dTTP
-
 Homo sapiens