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Literature summary extracted from

  • Bloch, K.; Chaykin, S.; Phillips, A.H.; De Waard, A.
    Mevalonic acid pyrophosphate and isopentenylpyrophosphate (1959), J. Biol. Chem., 234, 2595-2604.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.4.2 ATP above 10 mM Saccharomyces cerevisiae

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.4.2 Co2+ can partially replace Mg2+ in activation Saccharomyces cerevisiae
2.7.4.2 Fe2+ can partially replace Mg2+ in activation Saccharomyces cerevisiae
2.7.4.2 Mg2+ divalent cation required, Mg2+ most efficient Saccharomyces cerevisiae
2.7.4.2 Mn2+ can partially replace Mg2+ in activation Saccharomyces cerevisiae
2.7.4.2 Zn2+ can partially replace Mg2+ in activation Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.4.2 ATP + (R)-5-phosphomevalonate Saccharomyces cerevisiae
-
 ADP + 5-diphosphomevalonate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.2 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.4.2 ammonium sulfate, ethanol, phosphate gel, DEAE-cellulose Saccharomyces cerevisiae

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.4.2 0.06
-
-
 Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.2 ATP + (R)-5-phosphomevalonate
-
 Saccharomyces cerevisiae ADP + 5-diphosphomevalonate
-
 ?
2.7.4.2 ATP + 5-phosphomevalonate maximal activity at 10 mM ATP Saccharomyces cerevisiae ADP + 5-diphosphomevalonate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.4.2 5.5 10
-
 Saccharomyces cerevisiae