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Literature summary extracted from

  • Jaber, M.; Koch, W.J.; Rockman, H.; Smith, B.; Bond, R.A.; Sulik, K.K.; Ross, J. Jr.; Lefkowitz, R.J.; Caron, M.G.; Giros, B.
    Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function (1996), Proc. Natl. Acad. Sci. USA, 93, 12974-12979.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.15 G protein betagamma-subunit required for maximum activity, targets beta-ARK 1 to the membrane, which presumably facilitates the precise orchestration of phosphorylation of only activated receptors Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.15 cloning and disruption of the beta-ARK 1 gene by homologous recombination, effects of gene disruption on the embryos Mus musculus
2.7.11.15 studies with beta-ARK 1 knockout mice Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.15 membrane G protein betagamma-subunit targets beta-ARK 1 to the membrane Mus musculus 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.11.15 80000
-
 Western blot analysis Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.15 additional information Mus musculus involved in the regulation of G protein-coupled receptor function, beta-ARK 1 appears to be the predominant GRK in early embryogenesis and plays a fundamental role in cardiac development, enzyme participates in intracellular signal transduction mechanisms, which regulate cardiogenesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.15 Mus musculus
-
 beta-ARK 1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.15 embryo whole embryo extract Mus musculus
-
2.7.11.15 heart adult heart Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.15 ATP + beta-adrenergic receptor
-
 Mus musculus ADP + phospho-beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + rhodopsin light-dependent, actual substrate: light-bleached rhodopsin Mus musculus ADP + phosphorhodopsin
-
 ?
2.7.11.15 ATP + rhodopsin in form of bovine rod outer segments Mus musculus ADP + phosphorhodopsin
-
 ?
2.7.11.15 additional information involved in the regulation of G protein-coupled receptor function, beta-ARK 1 appears to be the predominant GRK in early embryogenesis and plays a fundamental role in cardiac development, enzyme participates in intracellular signal transduction mechanisms, which regulate cardiogenesis Mus musculus ?
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.15 ATP
-
 Mus musculus