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Literature summary extracted from

  • Park, H.; Kaushik, V.K.; Constant, S.; Prentki, M.; Przybytkowski, E.; Ruderman, N.B.; Saha, A.K.
    Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise (2002), J. Biol. Chem., 277, 32571-32577.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.31 5'-AMP
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.4.1.2 ATP + acetyl-CoA + HCO3- Rattus norvegicus key enzyme of fatty acid biosynthesis, involved in regulation of fatty acid uptake into mitochondria ADP + phosphate + malonyl-CoA
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- Rattus norvegicus Sprague-Dawley key enzyme of fatty acid biosynthesis, involved in regulation of fatty acid uptake into mitochondria ADP + phosphate + malonyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.31 Rattus norvegicus
-
 Sprague-Dawley
-
2.7.11.31 Rattus norvegicus Sprague-Dawley
-
 Sprague-Dawley
-
6.4.1.2 Rattus norvegicus
-
 male sprague-dawley rats
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
6.4.1.2 phosphoprotein enzyme is phosphorylated and inactivated by AMP-activated protein kinase Rattus norvegicus

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.31
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.31 adipose tissue
-
 Rattus norvegicus
-
2.7.11.31 liver
-
 Rattus norvegicus
-
2.7.11.31 skeletal muscle
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.31 ATP + acetyl-CoA carboxylase
-
 Rattus norvegicus ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
2.7.11.31 ATP + acetyl-CoA carboxylase
-
 Rattus norvegicus Sprague-Dawley ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
2.7.11.31 ATP + [malonylCoAdecarboxylase]
-
 Rattus norvegicus ADP + [malonylCoAdecarboxylase]phosphate
-
 ?
2.7.11.31 ATP + [malonylCoAdecarboxylase]
-
 Rattus norvegicus Sprague-Dawley ADP + [malonylCoAdecarboxylase]phosphate
-
 ?
2.7.11.31 ATP + [sn-glycerol-3-phosphate acyltransferase]
-
 Rattus norvegicus ADP + [sn-glycerol-3-phosphate acyltransferase]phosphate
-
 ?
2.7.11.31 ATP + [sn-glycerol-3-phosphate acyltransferase]
-
 Rattus norvegicus Sprague-Dawley ADP + [sn-glycerol-3-phosphate acyltransferase]phosphate
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3-
-
 Rattus norvegicus ADP + phosphate + malonyl-CoA
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- key enzyme of fatty acid biosynthesis, involved in regulation of fatty acid uptake into mitochondria Rattus norvegicus ADP + phosphate + malonyl-CoA
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3-
-
 Rattus norvegicus Sprague-Dawley ADP + phosphate + malonyl-CoA
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- key enzyme of fatty acid biosynthesis, involved in regulation of fatty acid uptake into mitochondria Rattus norvegicus Sprague-Dawley ADP + phosphate + malonyl-CoA
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
6.4.1.2 biotin enzyme-bound Rattus norvegicus