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Literature summary extracted from

  • Santini, F.; Pinchera, A.; Ceccarini, G.; Castagna, M.; Rosellini, V.; Mammoli, C.; Montanelli, L.; Zucchi, V.; Chopra, I.J.; Chiovato, L.
    Evidence for a role of the type III-iodothyronine deiodinase in the regulation of 3,5,3'-triiodothyronine content in the human central nervous system (2001), Eur. J. Endocrinol., 144, 577-583.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.21.99.3 3,3',5'-triiodo-L-thyronine no effect up to 100 nM Homo sapiens
1.21.99.3 3,3',5,5'-tetraiodo-L-thyronine substrate inhibition of isozyme type III Homo sapiens
1.21.99.3 3,3',5-triiodo-L-thyronine substrate inhibition of isozyme type III, complete inhibition at 25 nM Homo sapiens
1.21.99.3 3,5-diiodo-L-thyronine substrate inhibition of isozyme type III Homo sapiens
1.21.99.3 aurothioglucose isozyme type III, 90% inhibition at 0.001 mM Homo sapiens
1.21.99.3 iopanoic acid 90% inhibition at 0.002 mM; isozyme type III Homo sapiens
1.21.99.3 additional information 3,3',5-triiodo-L-thyronine sulfate has no effect on isozyme type III in hippocampus up to 100 nM Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.21.99.3 0.000011
-
3,3',5'-triiodo-L-thyronine pH 7.4, 37°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.21.99.3 microsome isozyme type III Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.21.99.3 3,3',5-triiodo-L-thyronine + AH2 Homo sapiens enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content 3,3'-diiodo-L-thyronine + iodide + A + H+ hormonally inactive ?
1.21.99.3 3,3',5-triiodo-L-thyronine + AH2 Homo sapiens enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content 3,3'-diiodo-L-thyronine + iodide + A + H+ i.e. 3,3'-diiodo-L-thyronine ?
1.21.99.3 L-thyroxine + AH2 Homo sapiens 5-deiodinase activity 3,3',5'-triiodo-L-thyronine + iodide + A + H+ hormonally inactive ?
1.21.99.3 L-thyroxine + AH2 Homo sapiens 5-deiodinase activity 3,3',5'-triiodo-L-thyronine + iodide + A + H+ enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content ?
1.21.99.3 L-thyroxine + AH2 Homo sapiens isozyme type III 3,3',5-triiodo-L-thyronine + iodide + A + H+
-
?
1.21.99.3 additional information Homo sapiens thyroid hormone is essential for maintaining normal neurological functions both during development and in adult life ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.21.99.3 Homo sapiens
-
isozyme type III
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.21.99.3 brain isozyme type III Homo sapiens
-
1.21.99.3 central nervous system isozyme type III Homo sapiens
-
1.21.99.3 hippocampus isozyme type III Homo sapiens
-
1.21.99.3 additional information isozyme type III ativity in brain areas, overview Homo sapiens
-
1.21.99.3 temporal cortex isozyme type III Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.21.99.3 additional information
-
-
Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.99.3 3,3',5-triiodo-L-thyronine + AH2 isozyme type III Homo sapiens 3,3'-diiodo-L-thyronine + iodide + A + H+ hormonally inactive ?
1.21.99.3 3,3',5-triiodo-L-thyronine + AH2 enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content Homo sapiens 3,3'-diiodo-L-thyronine + iodide + A + H+ hormonally inactive ?
1.21.99.3 3,3',5-triiodo-L-thyronine + AH2 enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content Homo sapiens 3,3'-diiodo-L-thyronine + iodide + A + H+ i.e. 3,3'-diiodo-L-thyronine ?
1.21.99.3 L-thyroxine + AH2 isozyme type III Homo sapiens 3,3',5'-triiodo-L-thyronine + iodide + A + H+ hormonally inactive ?
1.21.99.3 L-thyroxine + AH2 5-deiodinase activity Homo sapiens 3,3',5'-triiodo-L-thyronine + iodide + A + H+ hormonally inactive ?
1.21.99.3 L-thyroxine + AH2 5-deiodinase activity Homo sapiens 3,3',5'-triiodo-L-thyronine + iodide + A + H+ enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content ?
1.21.99.3 L-thyroxine + AH2 isozyme type III Homo sapiens 3,3',5-triiodo-L-thyronine + iodide + A + H+
-
?
1.21.99.3 additional information thyroid hormone is essential for maintaining normal neurological functions both during development and in adult life Homo sapiens ?
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.21.99.3 37
-
assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.21.99.3 7.4
-
assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.21.99.3 dithiothreitol
-
Homo sapiens