EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.21.99.3 | 3,3',5'-triiodo-L-thyronine | no effect up to 100 nM | Homo sapiens | |
1.21.99.3 | 3,3',5,5'-tetraiodo-L-thyronine | substrate inhibition of isozyme type III | Homo sapiens | |
1.21.99.3 | 3,3',5-triiodo-L-thyronine | substrate inhibition of isozyme type III, complete inhibition at 25 nM | Homo sapiens | |
1.21.99.3 | 3,5-diiodo-L-thyronine | substrate inhibition of isozyme type III | Homo sapiens | |
1.21.99.3 | aurothioglucose | isozyme type III, 90% inhibition at 0.001 mM | Homo sapiens | |
1.21.99.3 | iopanoic acid | 90% inhibition at 0.002 mM; isozyme type III | Homo sapiens | |
1.21.99.3 | additional information | 3,3',5-triiodo-L-thyronine sulfate has no effect on isozyme type III in hippocampus up to 100 nM | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.21.99.3 | 0.000011 | - |
3,3',5'-triiodo-L-thyronine | pH 7.4, 37°C | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.21.99.3 | microsome | isozyme type III | Homo sapiens | - |
- |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.21.99.3 | 3,3',5-triiodo-L-thyronine + AH2 | Homo sapiens | enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content | 3,3'-diiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
1.21.99.3 | 3,3',5-triiodo-L-thyronine + AH2 | Homo sapiens | enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content | 3,3'-diiodo-L-thyronine + iodide + A + H+ | i.e. 3,3'-diiodo-L-thyronine | ? | |
1.21.99.3 | L-thyroxine + AH2 | Homo sapiens | 5-deiodinase activity | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
1.21.99.3 | L-thyroxine + AH2 | Homo sapiens | 5-deiodinase activity | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content | ? | |
1.21.99.3 | L-thyroxine + AH2 | Homo sapiens | isozyme type III | 3,3',5-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
1.21.99.3 | additional information | Homo sapiens | thyroid hormone is essential for maintaining normal neurological functions both during development and in adult life | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.21.99.3 | Homo sapiens | - |
isozyme type III | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.21.99.3 | brain | isozyme type III | Homo sapiens | - |
1.21.99.3 | central nervous system | isozyme type III | Homo sapiens | - |
1.21.99.3 | hippocampus | isozyme type III | Homo sapiens | - |
1.21.99.3 | additional information | isozyme type III ativity in brain areas, overview | Homo sapiens | - |
1.21.99.3 | temporal cortex | isozyme type III | Homo sapiens | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.21.99.3 | additional information | - |
- |
Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.21.99.3 | 3,3',5-triiodo-L-thyronine + AH2 | isozyme type III | Homo sapiens | 3,3'-diiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
1.21.99.3 | 3,3',5-triiodo-L-thyronine + AH2 | enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content | Homo sapiens | 3,3'-diiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
1.21.99.3 | 3,3',5-triiodo-L-thyronine + AH2 | enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content | Homo sapiens | 3,3'-diiodo-L-thyronine + iodide + A + H+ | i.e. 3,3'-diiodo-L-thyronine | ? | |
1.21.99.3 | L-thyroxine + AH2 | isozyme type III | Homo sapiens | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
1.21.99.3 | L-thyroxine + AH2 | 5-deiodinase activity | Homo sapiens | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | hormonally inactive | ? | |
1.21.99.3 | L-thyroxine + AH2 | 5-deiodinase activity | Homo sapiens | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content | ? | |
1.21.99.3 | L-thyroxine + AH2 | isozyme type III | Homo sapiens | 3,3',5-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
1.21.99.3 | additional information | thyroid hormone is essential for maintaining normal neurological functions both during development and in adult life | Homo sapiens | ? | - |
? |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.21.99.3 | 37 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.21.99.3 | 7.4 | - |
assay at | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.21.99.3 | dithiothreitol | - |
Homo sapiens |