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Literature summary extracted from

  • Croteau, W.; Whittemore, S.L.; Schneider, M.J.; St Germain, D.L.
    Cloning and expression of a cDNA for a mammalian type III iodothyronine deiodinase (1995), J. Biol. Chem., 270, 16569-16575.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.21.99.3 screening of neonatal skin cDNA library, DNA sequence determination and analysis, isozyme type III, an in-frame TGA codon encodes a selenocysteine residue, functional translation in Xenopus laevis oocytes, catalytis properties of recombinant and native enzyme are identical Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.21.99.3 aurothioglucose no inhibition, isozyme type III Rattus norvegicus
1.21.99.3 additional information no inhibition of 5-deiodinase activity by propylthiouracil Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.21.99.3 Rattus norvegicus P49897 selenoprotein
-
1.21.99.3 Rattus norvegicus P49897 isozyme type III
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.21.99.3 skin
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.99.3 3,3',5'-triiodo-L-thyronine + AH2 no activity Rattus norvegicus 3,3'-diiodo-L-thyronine + iodide + A + H+
-
?
1.21.99.3 3,3',5-triiodo-L-thyronine + AH2 best substrate Rattus norvegicus 3,3'-diiodo-L-thyronine + iodide + A + H+ hormonally inactive ?
1.21.99.3 3,3',5-triiodo-L-thyronine + AH2 isozyme type III Rattus norvegicus 3,3'-diiodo-L-thyronine + iodide + A + H+ hormonally inactive ?
1.21.99.3 L-thyroxine + AH2 preferred substrate Rattus norvegicus 3,3',5'-triiodo-L-thyronine + iodide + A + H+ hormonally inactive ?
1.21.99.3 L-thyroxine + AH2 isozyme type III Rattus norvegicus 3,3',5'-triiodo-L-thyronine + iodide + A + H+ hormonally inactive ?
1.21.99.3 L-thyroxine + AH2 5-deiodinase activity Rattus norvegicus 3,3',5'-triiodo-L-thyronine + iodide + A + H+ hormonally inactive ?
1.21.99.3 L-thyroxine + AH2 no activity Rattus norvegicus 3,3',5-triiodo-L-thyronine + iodide + A + H+
-
?