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Literature summary extracted from

  • Mori, K.; Yoshida, K.; Kayama, T.; Kaise, N.; Fukazawa, H.; Kiso, Y.; Kikuchi, K.; Aizawa, Y.; Abe, K.
    Thyroxine 5-deiodinase in human brain tumors (1993), J. Clin. Endocrinol. Metab., 77, 1198-1202.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.21.99.3 aurothioglucose 3,3',5,5'-tetraiodo-L-thyronine 5-deiodinase activity Homo sapiens
1.21.99.3 iopanoic acid 3,3',5,5'-tetraiodo-L-thyronine 5-deiodinase activity Homo sapiens
1.21.99.3 additional information no inhibition of 5-deiodinase activity by propylthiouracil Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.21.99.3 0.000107
-
 L-thyroxine pH 8.0, 37°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.21.99.3 Homo sapiens
-
 5-deiodinase activity
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.21.99.3 astrocytoma cell
-
 Homo sapiens
-
1.21.99.3 brain cancer cell 5-deiodinase activity Homo sapiens
-
1.21.99.3 glioblastoma cell
-
 Homo sapiens
-
1.21.99.3 lymphoma cell malignant Homo sapiens
-
1.21.99.3 medulloblastoma cell
-
 Homo sapiens
-
1.21.99.3 meningioma cell
-
 Homo sapiens
-
1.21.99.3 oligodendroglioma cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.21.99.3 additional information
-
 3,3',5,5'-tetraiodo-L-thyronine 5-deiodinase activity in brain carcinoma types Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.99.3 L-thyroxine + AH2 5-deiodinase activity Homo sapiens 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.21.99.3 37
-
 3,3',5,5'-tetraiodo-L-thyronine 5-deiodinase activity Homo sapiens

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.21.99.3 70
-
 30 min, inactivation of 5-deiodinase Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.21.99.3 8
-
 3,3',5,5'-tetraiodo-L-thyronine 5deiodinase activity Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.21.99.3 dithiothreitol absolutely required Homo sapiens
1.21.99.3 dithiothreitol optimal at 50-100 mM Homo sapiens