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Literature summary extracted from

  • Fekkes, D.; Hennemann, G.; Visser, T.J.
    Properties of detergent-dispersed iodothyronine 5- and 5'-deiodinase activities from rat liver (1983), Biochim. Biophys. Acta, 742, 324-333.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.21.99.3 Phospholipids possible regulatory role Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.21.99.3 additional information
-
 additional information
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.21.99.3 microsome
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.21.99.3 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.21.99.3 partial, 3fold Rattus norvegicus

Reaction

EC Number Reaction Comment Organism Reaction ID
1.21.99.3 3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor enzyme has both thyroxine 5-deiodinase and thyroxine 5'-deiodinase activities Rattus norvegicus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.21.99.3 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.99.3 L-thyroxine + AH2 5-deiodinase activity Rattus norvegicus 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
1.21.99.3 L-thyroxine + AH2 5'-deiodinase activity Rattus norvegicus 3,3',5-triiodo-L-thyronine + iodide + A + H+
-
 ?

pI Value

EC Number Organism Comment pI Value Maximum pI Value
1.21.99.3 Rattus norvegicus
-
-
 6.4
1.21.99.3 Rattus norvegicus in presence of ammonium sulfate
-
 9.5