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Literature summary extracted from

  • Adams, B.; Lowe, D.J.; Smith, A.T.; Scazzocchio, C.; Demais, S.; Bray, R.C.
    Expression of Drosophila melanogaster xanthine dehydrogenase in Aspergillus nidulans and some properties of the recombinant enzyme (2002), Biochem. J., 362, 223-229.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.17.1.4 expression in Aspergillus nidulans Drosophila melanogaster

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.17.1.4 0.032
-
 xanthine electron acceptor: NAD+ Drosophila melanogaster

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.17.1.4 Iron-sulfur-center
-
 Drosophila melanogaster
1.17.1.4 molybdenum-center
-
 Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.1.4 xanthine + NAD+ + H2O Drosophila melanogaster
-
 urate + NADH
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.1.4 Drosophila melanogaster
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.17.1.4 to homogeneity, recombinant enzyme Drosophila melanogaster

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.1.4 acetaldehyde + NAD+ + H2O considerable activity for the recombinant enzyme Drosophila melanogaster acetate + NADH + H+
-
 ?
1.17.1.4 xanthine + NAD+ + H2O
-
 Drosophila melanogaster urate + NADH
-
 ?
1.17.1.4 xanthine + phenazine methosulfate + cytochrome c + H2O
-
 Drosophila melanogaster urate + ?
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.17.1.4 31
-
 xanthine recombinant enzyme, electron acceptor: phenazine methosulfate-cytochrome c Drosophila melanogaster

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
1.17.1.4 9.2
-
 recombinant enzyme, half-life: 10-15 h at 0-4°C Drosophila melanogaster

Cofactor

EC Number Cofactor Comment Organism Structure
1.17.1.4 FAD
-
 Drosophila melanogaster
1.17.1.4 additional information
-
 Drosophila melanogaster
1.17.1.4 NAD+
-
 Drosophila melanogaster