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Literature summary extracted from

  • Brushaber, K.R.; O'Toole, G.A.; Escalante-Semerena, J.C.
    CobD, a novel enzyme with L-threonine-O-3-phosphate decarboxylase activity, is responsible for the synthesis of (R)-1-amino-2-propanol O-2-phosphate, a proposed new intermediate in cobalamin biosynthesis in Salmonella typhimurium LT2 (1998), J. Biol. Chem., 273, 2684-2691.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.81 cloned, sequenced and overexpressed Salmonella enterica subsp. enterica serovar Typhimurium

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.1.81 40800
-
 predicted from nucleotide sequence Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.81 L-threonine O-3-phosphate Salmonella enterica subsp. enterica serovar Typhimurium
-
 (R)-1-aminopropan-2-yl phosphate + CO2
-
 ?
4.1.1.81 L-threonine O-3-phosphate Salmonella enterica subsp. enterica serovar Typhimurium adenosylcobalamin biosynthesis, end product of the corrin ring biosynthetic pathway is 5'-deoxyadenosylcobinamide phosphate, not 5'-deoxyadenosylcobinamide (R)-1-aminopropan-2-yl phosphate + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.81 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-
4.1.1.81 Salmonella enterica subsp. enterica serovar Typhimurium P97084
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.81 L-threonine O-3-phosphate
-
 Salmonella enterica subsp. enterica serovar Typhimurium (R)-1-aminopropan-2-yl phosphate + CO2
-
 ?
4.1.1.81 L-threonine O-3-phosphate enzyme shows stereospecificity for the L-isomer, unable to decarboxylate the D-isomer Salmonella enterica subsp. enterica serovar Typhimurium (R)-1-aminopropan-2-yl phosphate + CO2
-
 ?
4.1.1.81 L-threonine O-3-phosphate adenosylcobalamin biosynthesis, end product of the corrin ring biosynthetic pathway is 5'-deoxyadenosylcobinamide phosphate, not 5'-deoxyadenosylcobinamide Salmonella enterica subsp. enterica serovar Typhimurium (R)-1-aminopropan-2-yl phosphate + CO2
-
 ?
4.1.1.81 additional information CobD does not have lactaldehyde aminotransferase activity Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.81 CobD
-
 Salmonella enterica subsp. enterica serovar Typhimurium