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Literature summary extracted from

  • Percy, A.K.; Carson, M.A.; Moore, J.F.; Waechter, C.J.
    Control of phosphatidylethanolamine metabolism in yeast: diacylglycerol ethanolaminephosphotransferase and diacylglycerol cholinephosphotransferase are separate enzymes (1984), Arch. Biochem. Biophys., 230, 69-81.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.8.1 1,2-diacylglycerol stimulated by exogenous 1,2-diacylglycerols, largest stimulation by 1,2-diolein and 1,2-diacylglycerol Saccharomyces cerevisiae
2.7.8.2 1,2-Dilaurin
-
 Saccharomyces cerevisiae
2.7.8.2 1,2-diolein highest stimulation of diacylglycerols tested Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.8.1 1,2-Dilaurin slight Saccharomyces cerevisiae
2.7.8.1 5'-AMP slight Saccharomyces cerevisiae
2.7.8.1 5'-CMP
-
 Saccharomyces cerevisiae
2.7.8.1 5'-GMP slight Saccharomyces cerevisiae
2.7.8.1 5'-UMP slight Saccharomyces cerevisiae
2.7.8.1 CDP
-
 Saccharomyces cerevisiae
2.7.8.1 CMP
-
 Saccharomyces cerevisiae
2.7.8.1 CTP
-
 Saccharomyces cerevisiae
2.7.8.1 DH-990 hypolidemic drug Saccharomyces cerevisiae
2.7.8.1 p-hydroxymercuribenzoate reversal by monothioglycerol Saccharomyces cerevisiae
2.7.8.2 5'-AMP little effect Saccharomyces cerevisiae
2.7.8.2 5'-CTP
-
 Saccharomyces cerevisiae
2.7.8.2 5'-GMP little effect Saccharomyces cerevisiae
2.7.8.2 5'-UMP little effect Saccharomyces cerevisiae
2.7.8.2 CDP
-
 Saccharomyces cerevisiae
2.7.8.2 CMP
-
 Saccharomyces cerevisiae
2.7.8.2 DH-990 hypolidemic drug Saccharomyces cerevisiae
2.7.8.2 p-hydroxymercuribenzoate
-
 Saccharomyces cerevisiae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.8.1 0.083
-
 CDP-ethanolamine 37°C, pH 8.0 Saccharomyces cerevisiae
2.7.8.2 additional information
-
 additional information
-
 Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.8.1 membrane
-
 Saccharomyces cerevisiae 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.8.1 Mn2+ required Saccharomyces cerevisiae
2.7.8.2 Mn2+ required Saccharomyces cerevisiae
2.7.8.2 Mn2+ 2-5 mM Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.1 Saccharomyces cerevisiae
-
-
-
2.7.8.2 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.1 CDP-ethanolamine + 1,2-diacylglycerol in presence of 5'-CMP Saccharomyces cerevisiae CMP + a phosphatidylethanolamine
-
 r
2.7.8.1 CDP-ethanolamine + 1,2-dioleoylglycerol
-
 Saccharomyces cerevisiae CMP + dioleoylphosphatidylethanolamine
-
 ?
2.7.8.2 CDP-choline + 1,2-diacylglycerol
-
 Saccharomyces cerevisiae CMP + a phosphatidylcholine
-
 r
2.7.8.2 CMP + phosphatidylcholine
-
 Saccharomyces cerevisiae CDP-choline + 1,2-diacylglycerol
-
 r

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.8.1 30 37
-
 Saccharomyces cerevisiae
2.7.8.2 30 45
-
 Saccharomyces cerevisiae

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.7.8.1 50
-
 t1/2: 8 min Saccharomyces cerevisiae
2.7.8.2 50
-
 t1/2: 1 min Saccharomyces cerevisiae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.8.1 8
-
-
 Saccharomyces cerevisiae
2.7.8.2 7
-
-
 Saccharomyces cerevisiae