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Literature summary extracted from

  • Hübscher, U.
    DNA polymerase holoenzymes (1984), Trends Biochem. Sci., 9, 390-393.
No PubMed abstract available

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.7.7 10000
-
 x * 140000 (alpha) + x * 37000 (beta) + x * 52000 (gamma) + x * 32000 (delta) + x * 25000 (epsilon) + x * 10000 (theta) + x * 78000 (tau) Escherichia coli
2.7.7.7 25000
-
 x * 140000 (alpha) + x * 37000 (beta) + x * 52000 (gamma) + x * 32000 (delta) + x * 25000 (epsilon) + x * 10000 (theta) + x * 78000 (tau) Escherichia coli
2.7.7.7 32000
-
 x * 140000 (alpha) + x * 37000 (beta) + x * 52000 (gamma) + x * 32000 (delta) + x * 25000 (epsilon) + x * 10000 (theta) + x * 78000 (tau) Escherichia coli
2.7.7.7 37000
-
 x * 140000 (alpha) + x * 37000 (beta) + x * 52000 (gamma) + x * 32000 (delta) + x * 25000 (epsilon) + x * 10000 (theta) + x * 78000 (tau) Escherichia coli
2.7.7.7 50000
-
 x * 182000 (alpha) + x * 60000 (beta) + x * 50000 (gamma), core polymerase Drosophila melanogaster
2.7.7.7 52000
-
 x * 140000 (alpha) + x * 37000 (beta) + x * 52000 (gamma) + x * 32000 (delta) + x * 25000 (epsilon) + x * 10000 (theta) + x * 78000 (tau) Escherichia coli
2.7.7.7 60000
-
 x * 182000 (alpha) + x * 60000 (beta) + x * 50000 (gamma), core polymerase Drosophila melanogaster
2.7.7.7 78000
-
 x * 140000 (alpha) + x * 37000 (beta) + x * 52000 (gamma) + x * 32000 (delta) + x * 25000 (epsilon) + x * 10000 (theta) + x * 78000 (tau) Escherichia coli
2.7.7.7 140000
-
 x * 140000 (alpha) + x * 37000 (beta) + x * 52000 (gamma) + x * 32000 (delta) + x * 25000 (epsilon) + x * 10000 (theta) + x * 78000 (tau) Escherichia coli
2.7.7.7 182000
-
 x * 182000 (alpha) + x * 60000 (beta) + x * 50000 (gamma), core polymerase Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.7 deoxynucleoside triphosphate + DNAn Drosophila melanogaster
-
 diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn Bos taurus
-
 diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn Escherichia coli polymerase III: role in replication of chromosomal DNA diphosphate + DNAn+1
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.7 Bos taurus
-
-
-
2.7.7.7 Drosophila melanogaster
-
-
-
2.7.7.7 Escherichia coli
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.7 thymus
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Drosophila melanogaster diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Escherichia coli diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Bos taurus diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn polymerase III: role in replication of chromosomal DNA Escherichia coli diphosphate + DNAn+1
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.7.7 ?
-
 Bos taurus
2.7.7.7 ? x * 140000 (alpha) + x * 37000 (beta) + x * 52000 (gamma) + x * 32000 (delta) + x * 25000 (epsilon) + x * 10000 (theta) + x * 78000 (tau) Escherichia coli
2.7.7.7 ? x * 182000 (alpha) + x * 60000 (beta) + x * 50000 (gamma), core polymerase Drosophila melanogaster
2.7.7.7 More multipolypeptide complex in prokaryotes and eukaryotes, three structural levels can be distinguished: 1. core polymerase (responsible for basic polymerization step), 2. DNA polymerase holoenzyme (composed of the core polymerase, which is responsible for the basic polymerization step and associated accessory proteins, a complex which is fully active on naturally occuring DNA templates), 3. holoenzyme embedded in a higher order structure, such as an asymmetric dimer or other complex which acts in concert with other known replication enzymes Drosophila melanogaster
2.7.7.7 More multipolypeptide complex in prokaryotes and eukaryotes, three structural levels can be distinguished: 1. core polymerase (responsible for basic polymerization step), 2. DNA polymerase holoenzyme (composed of the core polymerase, which is responsible for the basic polymerization step and associated accessory proteins, a complex which is fully active on naturally occuring DNA templates), 3. holoenzyme embedded in a higher order structure, such as an asymmetric dimer or other complex which acts in concert with other known replication enzymes Escherichia coli
2.7.7.7 More multipolypeptide complex in prokaryotes and eukaryotes, three structural levels can be distinguished: 1. core polymerase (responsible for basic polymerization step), 2. DNA polymerase holoenzyme (composed of the core polymerase, which is responsible for the basic polymerization step and associated accessory proteins, a complex which is fully active on naturally occuring DNA templates), 3. holoenzyme embedded in a higher order structure, such as an asymmetric dimer or other complex which acts in concert with other known replication enzymes Bos taurus