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Literature summary extracted from

  • Wang, T.S.F.
    Eukaryotic DNA polymerases (1991), Annu. Rev. Biochem., 60, 513-552.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.7.7 proliferating cell nuclear antigen PCNA, specific auxiliary factor stimulating DNA polymerase delta Gallus gallus
2.7.7.7 proliferating cell nuclear antigen PCNA, specific auxiliary factor stimulating DNA polymerase delta Drosophila melanogaster
2.7.7.7 proliferating cell nuclear antigen PCNA, specific auxiliary factor stimulating DNA polymerase delta Mammalia
2.7.7.7 proliferating cell nuclear antigen PCNA, specific auxiliary factor stimulating DNA polymerase delta Homo sapiens
2.7.7.7 proliferating cell nuclear antigen PCNA, specific auxiliary factor stimulating DNA polymerase delta Bos taurus
2.7.7.7 proliferating cell nuclear antigen PCNA, specific auxiliary factor stimulating DNA polymerase delta Xenopus laevis
2.7.7.7 Replication factor A RF-A, multisubunit single-stranded DNA-binding protein, functions as an auxiliary protein for both polymerases alpha and delta, required for initiation and elongation stages of in vitro SV40 DNA replication Gallus gallus
2.7.7.7 Replication factor A RF-A, multisubunit single-stranded DNA-binding protein, functions as an auxiliary protein for both polymerases alpha and delta, required for initiation and elongation stages of in vitro SV40 DNA replication Drosophila melanogaster
2.7.7.7 Replication factor A RF-A, multisubunit single-stranded DNA-binding protein, functions as an auxiliary protein for both polymerases alpha and delta, required for initiation and elongation stages of in vitro SV40 DNA replication Mammalia
2.7.7.7 Replication factor A RF-A, multisubunit single-stranded DNA-binding protein, functions as an auxiliary protein for both polymerases alpha and delta, required for initiation and elongation stages of in vitro SV40 DNA replication Homo sapiens
2.7.7.7 Replication factor A RF-A, multisubunit single-stranded DNA-binding protein, functions as an auxiliary protein for both polymerases alpha and delta, required for initiation and elongation stages of in vitro SV40 DNA replication Bos taurus
2.7.7.7 Replication factor A RF-A, multisubunit single-stranded DNA-binding protein, functions as an auxiliary protein for both polymerases alpha and delta, required for initiation and elongation stages of in vitro SV40 DNA replication Xenopus laevis
2.7.7.7 Replication factor C RF-C, multisubunit protein complex with primer/template binding and DNA-dependent ATPase activity, has a profound effect on leading-strand DNA synthesis Gallus gallus
2.7.7.7 Replication factor C RF-C, multisubunit protein complex with primer/template binding and DNA-dependent ATPase activity, has a profound effect on leading-strand DNA synthesis Drosophila melanogaster
2.7.7.7 Replication factor C RF-C, multisubunit protein complex with primer/template binding and DNA-dependent ATPase activity, has a profound effect on leading-strand DNA synthesis Mammalia
2.7.7.7 Replication factor C RF-C, multisubunit protein complex with primer/template binding and DNA-dependent ATPase activity, has a profound effect on leading-strand DNA synthesis Homo sapiens
2.7.7.7 Replication factor C RF-C, multisubunit protein complex with primer/template binding and DNA-dependent ATPase activity, has a profound effect on leading-strand DNA synthesis Bos taurus
2.7.7.7 Replication factor C RF-C, multisubunit protein complex with primer/template binding and DNA-dependent ATPase activity, has a profound effect on leading-strand DNA synthesis Xenopus laevis

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.7 overview: genetic structure and predicted functional domains Drosophila melanogaster
2.7.7.7 overview: genetic structure and predicted functional domains Homo sapiens
2.7.7.7 overview: genetic structure and predicted functional domains Saccharomyces cerevisiae
2.7.7.7 overview: genetic structure and predicted functional domains Bos taurus
2.7.7.7 polymerase beta, overexpressed in Escherichia coli Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.7 2-(p-n-Butylanilino)-2'-deoxyadenosine 5'-triphosphate DNA polymerase alpha Bos taurus
2.7.7.7 2-(p-n-Butylanilino)-2'-deoxyadenosine 5'-triphosphate DNA polymerase alpha Drosophila melanogaster
2.7.7.7 2-(p-n-Butylanilino)-2'-deoxyadenosine 5'-triphosphate DNA polymerase alpha Gallus gallus
2.7.7.7 2-(p-n-Butylanilino)-2'-deoxyadenosine 5'-triphosphate DNA polymerase alpha Homo sapiens
2.7.7.7 2-(p-n-Butylanilino)-2'-deoxyadenosine 5'-triphosphate DNA polymerase alpha Mammalia
2.7.7.7 2-(p-n-Butylanilino)-2'-deoxyadenosine 5'-triphosphate DNA polymerase alpha Xenopus laevis
2.7.7.7 aphidicolin DNA polymerase alpha; DNA polymerase delta; DNA polymerase epsilon Bos taurus
2.7.7.7 aphidicolin DNA polymerase alpha; DNA polymerase delta; DNA polymerase epsilon Drosophila melanogaster
2.7.7.7 aphidicolin DNA polymerase alpha; DNA polymerase delta; DNA polymerase epsilon Gallus gallus
2.7.7.7 aphidicolin DNA polymerase alpha; DNA polymerase delta; DNA polymerase epsilon Homo sapiens
2.7.7.7 aphidicolin DNA polymerase alpha; DNA polymerase delta; DNA polymerase epsilon Mammalia
2.7.7.7 aphidicolin
-
 Saccharomyces cerevisiae
2.7.7.7 aphidicolin DNA polymerase alpha; DNA polymerase delta; DNA polymerase epsilon Xenopus laevis
2.7.7.7 Carbonyldiphosphonate DNA polymerase delta; no inhibition of polymerase alpha Bos taurus
2.7.7.7 Carbonyldiphosphonate DNA polymerase delta; no inhibition of polymerase alpha Drosophila melanogaster
2.7.7.7 Carbonyldiphosphonate DNA polymerase delta; no inhibition of polymerase alpha Gallus gallus
2.7.7.7 Carbonyldiphosphonate DNA polymerase delta; no inhibition of polymerase alpha Homo sapiens
2.7.7.7 Carbonyldiphosphonate DNA polymerase delta; no inhibition of polymerase alpha Mammalia
2.7.7.7 Carbonyldiphosphonate DNA polymerase delta; no inhibition of polymerase alpha Xenopus laevis
2.7.7.7 Dideoxynucleoside 5'-triphosphate DNA polymerase beta Bos taurus
2.7.7.7 Dideoxynucleoside 5'-triphosphate DNA polymerase beta Drosophila melanogaster
2.7.7.7 Dideoxynucleoside 5'-triphosphate DNA polymerase beta Gallus gallus
2.7.7.7 Dideoxynucleoside 5'-triphosphate DNA polymerase beta Homo sapiens
2.7.7.7 Dideoxynucleoside 5'-triphosphate DNA polymerase beta Mammalia
2.7.7.7 Dideoxynucleoside 5'-triphosphate DNA polymerase beta Xenopus laevis
2.7.7.7 additional information no inhibition by dideoxynucleoside 5'-triphosphate; no inhibition of DNA polymerase beta and gamma by aphidicolin; no inhibition of DNA polymerase beta by N-ethylmaleimide; no inhibition of DNA polymerase beta, gamma, delta, epsilon by 2-(p-n-butylanilino)-2'-deoxyadenosine 5'-triphosphate; no inhibition of polymerase alpha and delta by dideoxynucleoside 5'-triphosphate Bos taurus
2.7.7.7 additional information no inhibition by dideoxynucleoside 5'-triphosphate; no inhibition of DNA polymerase beta and gamma by aphidicolin; no inhibition of DNA polymerase beta by N-ethylmaleimide; no inhibition of DNA polymerase beta, gamma, delta, epsilon by 2-(p-n-butylanilino)-2'-deoxyadenosine 5'-triphosphate; no inhibition of polymerase alpha and delta by dideoxynucleoside 5'-triphosphate Drosophila melanogaster
2.7.7.7 additional information no inhibition by dideoxynucleoside 5'-triphosphate; no inhibition of DNA polymerase beta and gamma by aphidicolin; no inhibition of DNA polymerase beta by N-ethylmaleimide; no inhibition of DNA polymerase beta, gamma, delta, epsilon by 2-(p-n-butylanilino)-2'-deoxyadenosine 5'-triphosphate; no inhibition of polymerase alpha and delta by dideoxynucleoside 5'-triphosphate Gallus gallus
2.7.7.7 additional information no inhibition by dideoxynucleoside 5'-triphosphate; no inhibition of DNA polymerase beta and gamma by aphidicolin; no inhibition of DNA polymerase beta by N-ethylmaleimide; no inhibition of DNA polymerase beta, gamma, delta, epsilon by 2-(p-n-butylanilino)-2'-deoxyadenosine 5'-triphosphate; no inhibition of polymerase alpha and delta by dideoxynucleoside 5'-triphosphate Homo sapiens
2.7.7.7 additional information no inhibition by dideoxynucleoside 5'-triphosphate; no inhibition of DNA polymerase beta and gamma by aphidicolin; no inhibition of DNA polymerase beta by N-ethylmaleimide; no inhibition of DNA polymerase beta, gamma, delta, epsilon by 2-(p-n-butylanilino)-2'-deoxyadenosine 5'-triphosphate; no inhibition of polymerase alpha and delta by dideoxynucleoside 5'-triphosphate Mammalia
2.7.7.7 additional information no inhibition by dideoxynucleoside 5'-triphosphate; no inhibition of DNA polymerase beta and gamma by aphidicolin; no inhibition of DNA polymerase beta by N-ethylmaleimide; no inhibition of DNA polymerase beta, gamma, delta, epsilon by 2-(p-n-butylanilino)-2'-deoxyadenosine 5'-triphosphate; no inhibition of polymerase alpha and delta by dideoxynucleoside 5'-triphosphate Xenopus laevis
2.7.7.7 N-ethylmaleimide DNA polymerase alpha, gamma, delta Bos taurus
2.7.7.7 N-ethylmaleimide DNA polymerase alpha, gamma, delta Drosophila melanogaster
2.7.7.7 N-ethylmaleimide DNA polymerase alpha, gamma, delta Gallus gallus
2.7.7.7 N-ethylmaleimide DNA polymerase alpha, gamma, delta Homo sapiens
2.7.7.7 N-ethylmaleimide DNA polymerase alpha, gamma, delta Mammalia
2.7.7.7 N-ethylmaleimide
-
 Saccharomyces cerevisiae
2.7.7.7 N-ethylmaleimide DNA polymerase alpha, gamma, delta Xenopus laevis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.7.7 Mg2+
-
 Gallus gallus
2.7.7.7 Mg2+
-
 Drosophila melanogaster
2.7.7.7 Mg2+
-
 Mammalia
2.7.7.7 Mg2+
-
 Homo sapiens
2.7.7.7 Mg2+
-
 Saccharomyces cerevisiae
2.7.7.7 Mg2+
-
 Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.7.7 35000
-
 x * 35000 + x * 125000, ratio 1:1, DNA polymerase gamma Drosophila melanogaster
2.7.7.7 40000
-
-
 Rattus norvegicus
2.7.7.7 40000
-
 vertebrates, DNA polymerase beta Gallus gallus
2.7.7.7 40000
-
 vertebrates, DNA polymerase beta Drosophila melanogaster
2.7.7.7 40000
-
 vertebrates, DNA polymerase beta Mammalia
2.7.7.7 40000
-
 vertebrates, DNA polymerase beta Homo sapiens
2.7.7.7 40000
-
 vertebrates, DNA polymerase beta Bos taurus
2.7.7.7 40000
-
 vertebrates, DNA polymerase beta Xenopus laevis
2.7.7.7 40000
-
 1 * 40000, DNA polymerase beta Saccharomyces cerevisiae
2.7.7.7 47000
-
 4 * 47000, heterotetramer, DNA polymerase gamma Gallus gallus
2.7.7.7 48000
-
 1 * 125000 catalytic subunit + 1 * 48000 subunit of unknown function, DNA polymerase delta Homo sapiens
2.7.7.7 48000
-
 1 * 125000 catalytic subunit + 1 * 48000 subunit of unknown function, DNA polymerase delta Bos taurus
2.7.7.7 125000
-
 DNA polymerase delta Bos taurus
2.7.7.7 125000
-
 x * 35000 + x * 125000, ratio 1:1, DNA polymerase gamma Drosophila melanogaster
2.7.7.7 125000
-
 1 * 125000 catalytic subunit + 1 * 48000 subunit of unknown function, DNA polymerase delta Homo sapiens
2.7.7.7 132000 200000 DNA polymerase epsilon Saccharomyces cerevisiae
2.7.7.7 140000
-
 DNA polymerase gamma Xenopus laevis
2.7.7.7 170000
-
-
 Saccharomyces cerevisiae
2.7.7.7 170000
-
-
 Bos taurus
2.7.7.7 170000
-
 polymerase delta Homo sapiens
2.7.7.7 215000
-
 DNA polymerase epsilon Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.7 deoxynucleoside triphosphate + DNAn Rattus norvegicus
-
 diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn Saccharomyces cerevisiae
-
 diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn Gallus gallus overview: physiological roles in replication and in DNA repair synthesis diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn Drosophila melanogaster overview: physiological roles in replication and in DNA repair synthesis diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn Mammalia overview: physiological roles in replication and in DNA repair synthesis diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn Homo sapiens overview: physiological roles in replication and in DNA repair synthesis diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn Bos taurus overview: physiological roles in replication and in DNA repair synthesis diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn Xenopus laevis overview: physiological roles in replication and in DNA repair synthesis diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn Gallus gallus DNA polymerase gamma: required for mitochondrial DNA replication but encoded in the nucleus diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn Drosophila melanogaster DNA polymerase gamma: required for mitochondrial DNA replication but encoded in the nucleus diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn Mammalia DNA polymerase gamma: required for mitochondrial DNA replication but encoded in the nucleus diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn Homo sapiens DNA polymerase gamma: required for mitochondrial DNA replication but encoded in the nucleus diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn Bos taurus DNA polymerase gamma: required for mitochondrial DNA replication but encoded in the nucleus diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn Xenopus laevis DNA polymerase gamma: required for mitochondrial DNA replication but encoded in the nucleus diphosphate + DNAn+1
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.7 Bos taurus
-
 5 cellular DNA template-dependent DNA polymerases are encoded by distinct genes: polymerase alpha, i.e. pol I, polymerase beta, only in vertebrates, polymerase gamma, required for mitochondrial DNA replication but encoded in the nucleus, polymerase delta, enzymes in mammalian cell contain tightly associated 3'-5'-exonuclease activities, 2 forms: proliferating cell nuclear antigen-dependent and a proliferating cell nuclear antigen-independent, also called DNA polymerase delta II, now named DNA polymerase epsilon, polymerase epsilon, tightly associated 3'-5'-exonuclease activity, formerly named DNA polymerase delta II
-
2.7.7.7 Drosophila melanogaster
-
 5 cellular DNA template-dependent DNA polymerases are encoded by distinct genes: polymerase alpha, i.e. pol I, polymerase beta, only in vertebrates, polymerase gamma, required for mitochondrial DNA replication but encoded in the nucleus, polymerase delta, enzymes in mammalian cell contain tightly associated 3'-5'-exonuclease activities, 2 forms: proliferating cell nuclear antigen-dependent and a proliferating cell nuclear antigen-independent, also called DNA polymerase delta II, now named DNA polymerase epsilon, polymerase epsilon, tightly associated 3'-5'-exonuclease activity, formerly named DNA polymerase delta II
-
2.7.7.7 Gallus gallus
-
 5 cellular DNA template-dependent DNA polymerases are encoded by distinct genes: polymerase alpha, i.e. pol I, polymerase beta, only in vertebrates, polymerase gamma, required for mitochondrial DNA replication but encoded in the nucleus, polymerase delta, enzymes in mammalian cell contain tightly associated 3'-5'-exonuclease activities, 2 forms: proliferating cell nuclear antigen-dependent and a proliferating cell nuclear antigen-independent, also called DNA polymerase delta II, now named DNA polymerase epsilon, polymerase epsilon, tightly associated 3'-5'-exonuclease activity, formerly named DNA polymerase delta II
-
2.7.7.7 Homo sapiens
-
 5 cellular DNA template-dependent DNA polymerases are encoded by distinct genes: polymerase alpha, i.e. pol I, polymerase beta, only in vertebrates, polymerase gamma, required for mitochondrial DNA replication but encoded in the nucleus, polymerase delta, enzymes in mammalian cell contain tightly associated 3'-5'-exonuclease activities, 2 forms: proliferating cell nuclear antigen-dependent and a proliferating cell nuclear antigen-independent, also called DNA polymerase delta II, now named DNA polymerase epsilon, polymerase epsilon, tightly associated 3'-5'-exonuclease activity, formerly named DNA polymerase delta II
-
2.7.7.7 Mammalia
-
-
-
2.7.7.7 Rattus norvegicus
-
 5 cellular DNA template-dependent DNA polymerases are encoded by distinct genes: polymerase alpha, i.e. pol I, polymerase beta, only in vertebrates, polymerase gamma, required for mitochondrial DNA replication but encoded in the nucleus, polymerase delta. Enzymes in mammalian cell contain tightly associated 3'-5'-exonuclease activities, 2 forms: proliferating cell nuclear antigen-dependent and a proliferating cell nuclear antigen-independent polymerase, also called DNA polymerase delta II, now named DNA polymerase epsilon, polymerase epsilon, tightly associated 3'-5'-exonuclease activity, formerly named DNA polymerase delta II
-
2.7.7.7 Saccharomyces cerevisiae
-
 pol II
-
2.7.7.7 Xenopus laevis
-
 5 cellular DNA template-dependent DNA polymerases are encoded by distinct genes: polymerase alpha, i.e. pol I, polymerase beta, only in vertebrates, polymerase gamma, required for mitochondrial DNA replication but encoded in the nucleus, polymerase delta, enzymes in mammalian cell contain tightly associated 3'-5'-exonuclease activities, 2 forms: proliferating cell nuclear antigen-dependent and a proliferating cell nuclear antigen-independent, also called DNA polymerase delta II, now named DNA polymerase epsilon, polymerase epsilon, tightly associated 3'-5'-exonuclease activity, formerly named DNA polymerase delta II
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.7.7 polymerase delta Homo sapiens

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.7.7 a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1 mechanism Gallus gallus
a
2.7.7.7 a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1 mechanism Drosophila melanogaster
a
2.7.7.7 a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1 mechanism Mammalia
a
2.7.7.7 a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1 mechanism Homo sapiens
a
2.7.7.7 a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1 mechanism Rattus norvegicus
a
2.7.7.7 a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1 mechanism Bos taurus
a
2.7.7.7 a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1 mechanism Xenopus laevis
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.7 HeLa cell
-
 Homo sapiens
-
2.7.7.7 placenta
-
 Homo sapiens
-
2.7.7.7 thymus
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Rattus norvegicus diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn
-
 Saccharomyces cerevisiae diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn DNA substrate: gapped duplex or single-stranded 5'-ends smaller than 100 nucleotides, pol I, pol II and pol III Gallus gallus diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn DNA substrate: gapped duplex or single-stranded 5'-ends smaller than 100 nucleotides, pol I, pol II and pol III Drosophila melanogaster diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn DNA substrate: gapped duplex or single-stranded 5'-ends smaller than 100 nucleotides, pol I, pol II and pol III Mammalia diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn DNA substrate: gapped duplex or single-stranded 5'-ends smaller than 100 nucleotides, pol I, pol II and pol III Homo sapiens diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn DNA substrate: gapped duplex or single-stranded 5'-ends smaller than 100 nucleotides, pol I, pol II and pol III Bos taurus diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn DNA substrate: gapped duplex or single-stranded 5'-ends smaller than 100 nucleotides, pol I, pol II and pol III Xenopus laevis diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn overview: physiological roles in replication and in DNA repair synthesis Gallus gallus diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn overview: physiological roles in replication and in DNA repair synthesis Drosophila melanogaster diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn overview: physiological roles in replication and in DNA repair synthesis Mammalia diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn overview: physiological roles in replication and in DNA repair synthesis Homo sapiens diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn overview: physiological roles in replication and in DNA repair synthesis Bos taurus diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn overview: physiological roles in replication and in DNA repair synthesis Xenopus laevis diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn DNA polymerase gamma: required for mitochondrial DNA replication but encoded in the nucleus Gallus gallus diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn DNA polymerase gamma: required for mitochondrial DNA replication but encoded in the nucleus Drosophila melanogaster diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn DNA polymerase gamma: required for mitochondrial DNA replication but encoded in the nucleus Mammalia diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn DNA polymerase gamma: required for mitochondrial DNA replication but encoded in the nucleus Homo sapiens diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn DNA polymerase gamma: required for mitochondrial DNA replication but encoded in the nucleus Bos taurus diphosphate + DNAn+1
-
 ?
2.7.7.7 deoxynucleoside triphosphate + DNAn DNA polymerase gamma: required for mitochondrial DNA replication but encoded in the nucleus Xenopus laevis diphosphate + DNAn+1
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.7.7 ?
-
 Saccharomyces cerevisiae
2.7.7.7 ?
-
 Bos taurus
2.7.7.7 ? x * 35000 + x * 125000, ratio 1:1, DNA polymerase gamma Drosophila melanogaster
2.7.7.7 ? DNA polymerase alpha is composed of: 1. a cluster of related high-molecular-weight polypeptides predominantly of 165000-180000 MW containing the catalytic function, 2. a polypeptide of 70000 MW with unknown catalytic function, 3. two polypeptides of 55000-60000 and 48000-49000 associated with primase activity Mammalia
2.7.7.7 dimer
-
 Drosophila melanogaster
2.7.7.7 dimer
-
 Saccharomyces cerevisiae
2.7.7.7 dimer 1 * 125000 catalytic subunit + 1 * 48000 subunit of unknown function, DNA polymerase delta Homo sapiens
2.7.7.7 dimer 1 * 125000 catalytic subunit + 1 * 48000 subunit of unknown function, DNA polymerase delta Bos taurus
2.7.7.7 monomer
-
 Gallus gallus
2.7.7.7 monomer
-
 Rattus norvegicus
2.7.7.7 monomer
-
 Bos taurus
2.7.7.7 monomer 1 * 215000, DNA polymerase epsilon Homo sapiens
2.7.7.7 monomer 1 * 140000, DNA polymerase gamma Xenopus laevis
2.7.7.7 monomer 1 * 40000, DNA polymerase beta Homo sapiens
2.7.7.7 monomer 1 * 40000, DNA polymerase beta Saccharomyces cerevisiae
2.7.7.7 monomer 1 * 40000, DNA polymerase beta Xenopus laevis
2.7.7.7 tetramer 4 * 47000, heterotetramer, DNA polymerase gamma Gallus gallus