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Literature summary extracted from

  • Guranowski, A.; Blanquet, S.
    Diadenosine 5,5-P1, P4-tetraphosphate alpha, beta-phosphorylase from yeast supports nucleoside diphosphate-phosphate exchange (1986), J. Biol. Chem., 261, 5943-5946.
    View publication on PubMed

General Stability

EC Number General Stability Organism
2.7.7.53 dithioerythritol stabilizes Saccharomyces cerevisiae
2.7.7.53 glycerol, 10%, stabilizes Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.53 AMP ADP/phosphate-exchange Saccharomyces cerevisiae
2.7.7.53 Ap3A ADP/phosphate-exchange Saccharomyces cerevisiae
2.7.7.53 Ca2+ weak, NDP-arsenolysis or NDP/phosphate-exchange reaction Saccharomyces cerevisiae
2.7.7.53 Cd2+ only NDP-arsenolysis or NDP/phosphate-exchange reaction Saccharomyces cerevisiae
2.7.7.53 Co2+ weak, NDP-arsenolysis or NDP/phosphate-exchange reaction Saccharomyces cerevisiae
2.7.7.53 Mg2+ only NDP-arsenolysis or NDP/phosphate-exchange reaction Saccharomyces cerevisiae
2.7.7.53 Mn2+ weak, NDP-arsenolysis or NDP/phosphate-exchange reaction Saccharomyces cerevisiae
2.7.7.53 P1,P4-bis(5'-adenosyl) tetraphosphate ADP/phosphate-exchange Saccharomyces cerevisiae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.7.53 additional information
-
additional information exchange reaction with ADP and analogues Saccharomyces cerevisiae
2.7.7.53 0.7
-
ADP ADP/phosphate-exchange, pH 7.0, 37°C Saccharomyces cerevisiae
2.7.7.53 0.7
-
GDP ADP/phosphate-exchange, pH 7.0, 37°C Saccharomyces cerevisiae
2.7.7.53 2
-
phosphate ADP/phosphate-exchange, pH 7.0, 37°C Saccharomyces cerevisiae

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.7.53 Mn2+ not NDP-arsenolysis or NDP/phosphate-exchange reaction Saccharomyces cerevisiae
2.7.7.53 additional information no divalent metal cation requirement for NDP-arsenolysis or NDP/phosphate-exchange reaction Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.53 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.53 additional information broad substrate specificity Saccharomyces cerevisiae ?
-
?
2.7.7.53 NDP + arsenate
-
Saccharomyces cerevisiae NMP + phosphate + ?
-
?
2.7.7.53 NDP + phosphate exchange reaction between beta-phosphate of NDP and phosphate from the medium Saccharomyces cerevisiae phosphate + NDP
-
r
2.7.7.53 P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
-
Saccharomyces cerevisiae ADP + ATP
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.7.53 37
-
assay at Saccharomyces cerevisiae

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.7.7.53 96
-
ADP ADP/phosphate-exchange, pH 7.0, 37°C Saccharomyces cerevisiae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.7.53 additional information
-
pH-dependence of NDP/phosphate-exchange reaction Saccharomyces cerevisiae
2.7.7.53 6.5
-
UDP + phosphate, NDP/phosphate-exchange, ADP, GDP or CDP + arsenate, NDP-arsenolysis Saccharomyces cerevisiae
2.7.7.53 7
-
ADP or CDP + phosphate, NDP/phosphate-exchange Saccharomyces cerevisiae
2.7.7.53 8
-
GDP + phosphate, NDP/phosphate-exchange Saccharomyces cerevisiae