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Literature summary extracted from

  • Kraus, G.; Behr, E.; Baier, M.; König, H.; Kurth, R.
    Simian immunodeficiency virus reverse transcriptase. Purification and partial characterization (1990), Eur. J. Biochem., 192, 207-213.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.49 ddATP competitive with respect to dATP, noncompetitive with respect to dCTP, dGTP and dTTP Simian immunodeficiency virus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.7.49 0.0028
-
 dTTP pH 7.6, 37°C Simian immunodeficiency virus
2.7.7.49 0.003
-
 dATP pH 7.6, 37°C Simian immunodeficiency virus
2.7.7.49 0.0047
-
 dCTP pH 7.6, 37°C Simian immunodeficiency virus
2.7.7.49 0.0055
-
 dGTP pH 7.6, 37°C Simian immunodeficiency virus

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.49 Simian immunodeficiency virus
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.7.49 0.067
-
-
 Simian immunodeficiency virus

Storage Stability

EC Number Storage Stability Organism
2.7.7.49 -70°C, stable for at least 6 months Simian immunodeficiency virus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.49 dATP + DNAn
-
 Simian immunodeficiency virus diphosphate + DNAn+1
-
 ?
2.7.7.49 dCTP + DNAn
-
 Simian immunodeficiency virus diphosphate + DNAn+1
-
 ?
2.7.7.49 deoxynucleoside triphosphate + DNAn the enzyme shows both RNA-dependent and DNA-dependent DNA synthesis activity and an associated RNAse H activity Simian immunodeficiency virus diphosphate + DNAn+1
-
 ?
2.7.7.49 dGTP + DNAn
-
 Simian immunodeficiency virus diphosphate + DNAn+1
-
 ?
2.7.7.49 dTTP + poly(rA)/(dT)18
-
 Simian immunodeficiency virus ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.7.49 8 8.2
-
 Simian immunodeficiency virus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.7.7.49 7 8.8 pH 7.0: about 40% of maximal activity, pH 8.8: about 75% of maximal activity Simian immunodeficiency virus