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Literature summary extracted from

  • Lykidis, A.; Jackson, P.; Rock, C.O.; Jackowski, S.
    The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content (1997), J. Biol. Chem., 272, 33402-33409.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.41 expression in COS cells Homo sapiens
2.7.8.11 yeast cDNA S45885 used to search, pis1 cDNA cloned and expressed in COS-7 cells Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.41 CTP + phosphatidate Homo sapiens the level of CDP-diacylglycerol synthetase 1 is not a critical determinant of cellular phosphatidylinositol content. This argues against a determining role of the activity in the regulation of phosphatidylinositol biosynthesis diphosphate + CDPdiacylglycerol
-
 ?
2.7.8.11 CDP-diacylglycerol + myo-inositol Homo sapiens
-
 CMP + phosphatidyl-1D-myo-inositol
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.41 Homo sapiens Q92903
-
-
2.7.8.11 Homo sapiens O14735 human
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.41 CTP + phosphatidate
-
 Homo sapiens diphosphate + CDPdiacylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate the level of CDP-diacylglycerol synthetase 1 is not a critical determinant of cellular phosphatidylinositol content. This argues against a determining role of the activity in the regulation of phosphatidylinositol biosynthesis Homo sapiens diphosphate + CDPdiacylglycerol
-
 ?
2.7.8.11 CDP-diacylglycerol + myo-inositol
-
 Homo sapiens CMP + phosphatidyl-1D-myo-inositol
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.7.8.11 PtdIns synthase
-
 Homo sapiens