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Literature summary extracted from

  • Focher, F.; Maga, G.; Bendiscioli, A.; Capobianco, M.; Colonna, F.; Garbesi, A.; Spadari, S.
    Stereospecificity of human DNA polymerases alpha, beta, gamma, delta and epsilon, HIV-reverse transcriptase, HSV-1 DNA polymerase, calf thymus terminal transferase and Escherichia coli DNA polymerase I in recognizing D- and L-thymidine 5'-triphosphate as substrate (1995), Nucleic Acids Res., 23, 2840-2847.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.7.7.31 medicine mechanism for inhibition of viral proliferation by L-nucleosides Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.31 L-beta-deoxythymidine-triphosphate i.e. L-dTTP, competitive Bos taurus
2.7.7.31 L-dTTP
-
Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.7.31 0.1
-
D-beta-deoxythymidine-triphosphate pH 6.6, 37°C, primer oligo(dT)20 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.31 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.31 thymus
-
Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.31 D-beta-deoxythymidine-triphosphate + DNAn
-
Bos taurus diphosphate + DNAn+1
-
?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.7.31 0.06
-
L-dTTP pH 6.6, 37°C, primer oligo(dT)20 Bos taurus