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Literature summary extracted from

  • Blakesley, R.W.; Boezi, J.A.
    A kinetic and structural characterization of adenosine-5-triphosphate: ribonucleic acid adenylyltransferase from Pseudomonas putida (1975), Biochim. Biophys. Acta, 414, 133-145.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.19 3'-dATP
-
 Homo sapiens
2.7.7.19 3'-dATP
-
 Pseudomonas putida
2.7.7.19 cordycepin
-
 Pseudomonas putida
2.7.7.19 diphosphate
-
 Homo sapiens
2.7.7.19 diphosphate
-
 Pseudomonas putida
2.7.7.19 Poly(dT)
-
 Pseudomonas putida
2.7.7.19 Poly(U)
-
 Pseudomonas putida
2.7.7.19 Rifamycin derivatives some derivatives are effective, others not Pseudomonas putida

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.7.19 additional information
-
 additional information
-
 Homo sapiens
2.7.7.19 additional information
-
 additional information
-
 Pseudomonas putida

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.19 particle-bound
-
 Pseudomonas putida
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.7.19 Mg2+
-
 Homo sapiens
2.7.7.19 Mg2+ more active in presence of Mg2+ than Mn2+ Pseudomonas putida
2.7.7.19 Mn2+
-
 Homo sapiens
2.7.7.19 Mn2+ more active in presence of Mg2+ than Mn2+ Pseudomonas putida

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.7.19 58000
-
-
 Pseudomonas putida
2.7.7.19 58000
-
 adenylyltransferase B, glycerol density gradient sedimentation Homo sapiens
2.7.7.19 185000
-
 adenylyltransferase A, glycerol density gradient sedimentation Pseudomonas putida

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.19 Homo sapiens
-
-
-
2.7.7.19 Pseudomonas putida
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.7.19 adenylyltransferase A and B Pseudomonas putida

Storage Stability

EC Number Storage Stability Organism
2.7.7.19 -20°C, stable for at least 3 months Pseudomonas putida

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.19 ATP + RNA primer: mixture of tRNA Pseudomonas putida diphosphate + RNA(A)n
-
 ?
2.7.7.19 ATP + RNA primer required Homo sapiens diphosphate + RNA(A)n
-
 ?
2.7.7.19 ATP + RNA primer required Pseudomonas putida diphosphate + RNA(A)n
-
 ?
2.7.7.19 ATP + RNA poly(A) and poly(C) minimally effective Pseudomonas putida diphosphate + RNA(A)n
-
 ?
2.7.7.19 ATP + RNA no primer: poly(dT) Pseudomonas putida diphosphate + RNA(A)n
-
 ?
2.7.7.19 ATP + RNA primer: oligonucleotides A-A-A-A and A-A-A Pseudomonas putida diphosphate + RNA(A)n
-
 ?
2.7.7.19 ATP + RNA no primer: poly(U) Pseudomonas putida diphosphate + RNA(A)n
-
 ?
2.7.7.19 CTP + RNA 12% of the activity with ATP, adenylyltransferase A Pseudomonas putida diphosphate + ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.7.19 9.5
-
 adenylyltransferase A Pseudomonas putida

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.7.19 0.6 1 3'-dATP
-
 Pseudomonas putida
2.7.7.19 4 10 Poly(U)
-
 Pseudomonas putida
2.7.7.19 4 10 Poly(dT)
-
 Pseudomonas putida