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Literature summary extracted from

  • Weinhold, P.A.; Rounsifer, M.E.; Feldman, D.A.
    The purification and characterization of CTP:phosphorylcholine cytidylyltransferase from rat liver (1986), J. Biol. Chem., 261, 5104-5110.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.15 4-chloromercuribenzoate
-
 Rattus norvegicus
2.7.7.15 5,5'-dithiobis(2-nitrobenzoate)
-
 Rattus norvegicus
2.7.7.15 Ca2+
-
 Rattus norvegicus
2.7.7.15 Mn2+
-
 Rattus norvegicus
2.7.7.15 additional information no inhibition by ATP; no inhibition by CDP; no inhibition by CMP Rattus norvegicus
2.7.7.15 N-ethylmaleimide CTP and phosphocholine protect Rattus norvegicus
2.7.7.15 phosphate maximal inhibition of 60% at 120 mM Rattus norvegicus
2.7.7.15 Zn2+
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.7.15 0.14
-
 phosphorylcholine pH 7.5 Rattus norvegicus
2.7.7.15 0.29
-
 CTP pH 7.5 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.15 cytosol
-
 Rattus norvegicus 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.7.15 39000
-
 2 * 39000 + 2 * 48000, SDS-PAGE Rattus norvegicus
2.7.7.15 48000
-
 2 * 39000 + 2 * 48000, SDS-PAGE Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.15 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.7.15
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.15 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.7.15 12.25
-
-
 Rattus norvegicus

Storage Stability

EC Number Storage Stability Organism
2.7.7.15 -70°C, stable in presence of Triton X-100 and 0.2 M potassium phosphate Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.15 CTP + choline phosphate
-
 Rattus norvegicus diphosphate + CDPcholine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.7.15 tetramer 2 * 39000 + 2 * 48000, SDS-PAGE Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.7.7.15 6 8 pH 6: about 80% of activity maximum, pH 8: about 60% of activity maximum Rattus norvegicus