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Literature summary extracted from

  • Yalowitz, J.A.; Jayaram, H.N.
    Modulation of cytotoxicity of benzamide riboside by expression of NMN adenylyltransferase (2002), Curr. Med. Chem., 9, 749-758.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.7.1 0.055
-
 tiazofurin YGR010W Saccharomyces cerevisiae
2.7.7.1 0.108
-
 ATP YGR010W Saccharomyces cerevisiae
2.7.7.1 0.11
-
 ATP YLR328W Saccharomyces cerevisiae
2.7.7.1 0.153
-
 NMN YGR010W Saccharomyces cerevisiae
2.7.7.1 0.19
-
 NMN YLR328W Saccharomyces cerevisiae
2.7.7.1 1.18
-
 ATP tiazofurin as second substrate, YGR010W Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.1 nucleus
-
 Mammalia 5634
-
2.7.7.1 nucleus chromatin-associated Homo sapiens 5634
-
2.7.7.1 nucleus chromatin-associated Saccharomyces cerevisiae 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.7.1 Ca2+
-
 Saccharomyces cerevisiae
2.7.7.1 Co2+
-
 Homo sapiens
2.7.7.1 Co2+
-
 Saccharomyces cerevisiae
2.7.7.1 Mg2+
-
 Homo sapiens
2.7.7.1 Mg2+
-
 Saccharomyces cerevisiae
2.7.7.1 Ni2+
-
 Homo sapiens
2.7.7.1 Ni2+
-
 Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.1 Homo sapiens
-
-
-
2.7.7.1 Mammalia
-
-
-
2.7.7.1 Mus musculus
-
-
-
2.7.7.1 Saccharomyces cerevisiae
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.1 B-16 cell
-
 Mus musculus
-
2.7.7.1 colonic cancer cell line colon 38 Mus musculus
-
2.7.7.1 erythrocyte
-
 Homo sapiens
-
2.7.7.1 Friend erythroleukemia cell line
-
 Mus musculus
-
2.7.7.1 L-1210 cell
-
 Mus musculus
-
2.7.7.1 Lewis lung carcinoma cell line
-
 Mus musculus
-
2.7.7.1 M5076 cell
-
 Mus musculus
-
2.7.7.1 P-388 cell Tiazofurin resistant Mus musculus
-
2.7.7.1 placenta
-
 Homo sapiens
-
2.7.7.1 placenta
-
 Mammalia
-
2.7.7.1 testis
-
 Mammalia
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.7.1 0.112
-
 tiazofurin as substrate, YGR010W Saccharomyces cerevisiae
2.7.7.1 13.8
-
 gene product YGR010W Saccharomyces cerevisiae
2.7.7.1 74.2
-
-
 Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.1 tiazofurin + ATP
-
 Homo sapiens tiazofurin adenine dinucleotide + diphosphate
-
 ?
2.7.7.1 tiazofurin + ATP YLR010W Saccharomyces cerevisiae tiazofurin adenine dinucleotide + diphosphate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.7.1 7.5 8.5 YGR010W Saccharomyces cerevisiae
2.7.7.1 7.8 8.4 YLR328W Saccharomyces cerevisiae