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Literature summary extracted from

  • Raffaelli, N.; Pisani, F.M.; Lorenzi, T.; Emanuelli, M.; Amici, A.; Ruggieri, S.; Magni, G.
    Characterization of nicotinamide mononucleotide adenylyltransferase from thermophilic archaea (1997), J. Bacteriol., 179, 7718-7723.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.1
-
Methanocaldococcus jannaschii

General Stability

EC Number General Stability Organism
2.7.7.1 chaotropic anions are strong destabilizers of the enzyme Saccharolobus solfataricus
2.7.7.1 increasing ionic strenght of NaCl and KCl stabilizes the thermal stability of the enzyme Saccharolobus solfataricus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.7.1 18600
-
x * 18600, SDS-PAGE Saccharolobus solfataricus
2.7.7.1 21500
-
x * 21500, SDS-PAGE Methanocaldococcus jannaschii
2.7.7.1 66000
-
-
Saccharolobus solfataricus
2.7.7.1 72000
-
gel filtration Methanocaldococcus jannaschii

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.1 Methanocaldococcus jannaschii
-
-
-
2.7.7.1 Saccharolobus solfataricus P57084
-
-
2.7.7.1 Saccharolobus solfataricus P2 P57084
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.7.1
-
Methanocaldococcus jannaschii
2.7.7.1
-
Saccharolobus solfataricus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.1 ATP + nicotinamide ribonucleotide i.e. NMN or nicotinamide mononucleotide Methanocaldococcus jannaschii diphosphate + NAD+
-
r
2.7.7.1 ATP + nicotinamide ribonucleotide i.e. NMN or nicotinamide mononucleotide Saccharolobus solfataricus diphosphate + NAD+
-
r
2.7.7.1 ATP + nicotinamide ribonucleotide i.e. NMN or nicotinamide mononucleotide Saccharolobus solfataricus P2 diphosphate + NAD+
-
r
2.7.7.1 ATP + nicotinate ribonucleotide i.e. nicotinate mononucleotide Saccharolobus solfataricus diphosphate + nicotinic acid-adenine dinucleotide
-
r
2.7.7.1 ATP + nicotinate ribonucleotide i.e. nicotinate mononucleotide Saccharolobus solfataricus P2 diphosphate + nicotinic acid-adenine dinucleotide
-
r

Subunits

EC Number Subunits Comment Organism
2.7.7.1 ? x * 18600, SDS-PAGE Saccharolobus solfataricus
2.7.7.1 ? x * 21500, SDS-PAGE Methanocaldococcus jannaschii

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
2.7.7.1 37 97 activity shows a continuous increase up to 97°C Saccharolobus solfataricus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.7.7.1 70
-
stable for 6 h Methanocaldococcus jannaschii
2.7.7.1 80
-
half life: 3 h Methanocaldococcus jannaschii
2.7.7.1 80
-
stable at least 2 h Saccharolobus solfataricus
2.7.7.1 85
-
half life: 75 min Saccharolobus solfataricus
2.7.7.1 90
-
half life: 30 min Saccharolobus solfataricus
2.7.7.1 90
-
half life: 1 h Methanocaldococcus jannaschii

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.7.1 5.8 7.8
-
Saccharolobus solfataricus