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Literature summary extracted from

  • Willemoes, M.; Hove-Jensen, B.; Larsen, S.
    Steady state kinetic model for the binding of substrates and allosteric effectors to Escherichia coli phosphoribosyl-diphosphate synthase (2000), J. Biol. Chem., 275, 35408-35412.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.6.1 ADP nonlinear competitive inhibition Escherichia coli
2.7.6.1 Ca2+
-
Escherichia coli
2.7.6.1 D-ribose 5-phosphate at unsaturating phosphate concentrations Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.6.1 0.041
-
Mg2+ pH 8.0, 37ºC, phosphate 50 mM Escherichia coli
2.7.6.1 0.059
-
Mg2+ pH 8.0, 37ºC, phosphate 5 mM Escherichia coli
2.7.6.1 0.19
-
D-ribose 5-phosphate pH 8.0, 37ºC, phosphate 50 mM Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.6.1 Mg2+ saturation with free Mg2+ results in hyperbolic activation by phosphate. At unsaturating free Mg2+ concentration, cooperative activation by phosphate is observed Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.6.1 ATP + D-ribose 5-phosphate Escherichia coli
-
AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
r

Organism

EC Number Organism UniProt Comment Textmining
2.7.6.1 Escherichia coli
-
-
-

Storage Stability

EC Number Storage Stability Organism
2.7.6.1 stored and diluted in the presence of phosphate 50 mM to maintain stability. With 2 mM MgATP2- or more, the enzyme is fully stable upon dilution and subsequent incubation at 37ºC Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.6.1 ATP + D-ribose 5-phosphate
-
Escherichia coli AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
r

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.6.1 37
-
assay at Escherichia coli

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.6.1 0.032
-
Ca2+ pH 8.0, 37ºC, D-ribose 5-phosphate 5 mM, Kis value Escherichia coli
2.7.6.1 0.047
-
Ca2+ pH 8.0, 37ºC, D-ribose 5-phosphate 5 mM, Kii value Escherichia coli
2.7.6.1 0.053
-
Ca2+ pH 8.0, 37ºC, D-ribose 5-phosphate 0.5 mM, Kis value Escherichia coli
2.7.6.1 0.11
-
Ca2+ pH 8.0, 37ºC, D-ribose 5-phosphate 0.5 mM, Kii value Escherichia coli
2.7.6.1 0.334
-
ADP pH 8.0, 37ºC, D-ribose 5-phosphate 0.5 mM, Kii value Escherichia coli
2.7.6.1 0.716
-
D-ribose 5-phosphate pH 8.0, 37ºC, Kii value Escherichia coli
2.7.6.1 1.18
-
D-ribose 5-phosphate pH 8.0, 37ºC, Kis value Escherichia coli