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Literature summary extracted from

  • Boehme, R.E.
    Phosphorylation of the antiviral precursor 9-(1,3-dihydroxy-2-propoxymethyl)guanine monophosphate by guanylate kinase isozymes (1984), J. Biol. Chem., 259, 12346-12349.
    View publication on PubMed

General Stability

EC Number General Stability Organism
2.7.4.8 bovine serum albumin stabilizes during purification Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.4.8 9-(1,3-dihydroxy-2-propylmethyl)guanine 5'-monophosphate
-
 Homo sapiens
2.7.4.8 9-(2-hydroxyethoxymethyl)guanine 5'-monophosphate
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.4.8 additional information
-
 additional information kinetic parameters of several substrates for 4 isoenzymes Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.4.8 Mg2+
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.8 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.4.8 4 isoenzymes purified by a method that includes GMP agarose chromatography and isoelectric focusing Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.4.8 erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.8 ATP + dGMP
-
 Homo sapiens ADP + dGDP
-
 r
2.7.4.8 ATP + GMP
-
 Homo sapiens ADP + GDP
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.4.8 0.043
-
 9-(1,3-dihydroxy-2-propylmethyl)guanine 5'-monophosphate pH 7.5, isoenzyme 4 Homo sapiens
2.7.4.8 0.052
-
 9-(1,3-dihydroxy-2-propylmethyl)guanine 5'-monophosphate pH 7.5, isoenzyme 4 Homo sapiens
2.7.4.8 0.06
-
 9-(1,3-dihydroxy-2-propylmethyl)guanine 5'-monophosphate pH 7.5, isoenzyme 1 Homo sapiens
2.7.4.8 0.067
-
 9-(1,3-dihydroxy-2-propylmethyl)guanine 5'-monophosphate pH 7.5, isoenzyme 2 Homo sapiens
2.7.4.8 0.45
-
 9-(2-hydroxyethoxymethyl)guanine 5'-monophosphate pH 7.5, isoenzyme 4 Homo sapiens
2.7.4.8 0.65
-
 9-(2-hydroxyethoxymethyl)guanine 5'-monophosphate pH 7.5, isoenzyme 2 Homo sapiens
2.7.4.8 0.67
-
 9-(2-hydroxyethoxymethyl)guanine 5'-monophosphate pH 7.5, isoenzyme 3 Homo sapiens
2.7.4.8 0.84
-
 9-(2-hydroxyethoxymethyl)guanine 5'-monophosphate pH 7.5, isoenzyme 1 Homo sapiens