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Literature summary extracted from

  • Lee, C.S.; O'Sullivan, W.J.
    Properties and mechanism of human erythrocyte phosphoglycerate kinase (1975), J. Biol. Chem., 250, 1275-1281.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.2.3 5,5'-dithiobis(2-nitrobenzoic acid) complete loss of activity Homo sapiens
2.7.2.3 Ca2+ inhibition above 1 mM Homo sapiens
2.7.2.3 Co2+ inhibits at high concentrations Homo sapiens
2.7.2.3 MgADP-
-
 Homo sapiens
2.7.2.3 MgGDP-
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.2.3 Ca2+ can partially replace Mg2+ in activation Homo sapiens
2.7.2.3 Co2+ can partially replace Mg2+ in activation Homo sapiens
2.7.2.3 divalent cation
-
 Homo sapiens
2.7.2.3 Mn2+ can partially replace Mg2+ in activation Homo sapiens
2.7.2.3 additional information no activation by: Sr2+ Homo sapiens
2.7.2.3 Zn2+ no activation Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.2.3 44500
-
 gel filtration Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.2.3 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.2.3 erythrocyte
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.2.3 600 700 purified enzyme Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.2.3 ATP + 3-phospho-D-glycerate absolute specificity for 3-phospho-D-glycerate Homo sapiens ADP + 1,3-diphosphoglycerate
-
 r
2.7.2.3 CTP + 3-phospho-D-glycerate no activity Homo sapiens CDP + 1,3-diphosphoglycerate
-
 ?
2.7.2.3 dATP + 3-phospho-D-glycerate 27% of the activity with ATP Homo sapiens dADP + 1,3-diphosphoglycerate
-
 ?
2.7.2.3 GTP + 3-phospho-D-glycerate 36% of the activity with ATP Homo sapiens GDP + 1,3-diphosphoglycerate
-
 ?
2.7.2.3 ITP + 3-phospho-D-glycerate 45% of the activity with ATP Homo sapiens IDP + 1,3-diphosphoglycerate
-
 ?
2.7.2.3 additional information also catalyzes ADP-ATP exchange reaction Homo sapiens ?
-
 ?
2.7.2.3 UTP + 3-phospho-D-glycerate no activity Homo sapiens UDP + 1,3-diphosphoglycerate
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.2.3 ADP
-
 Homo sapiens
2.7.2.3 ATP true substrate is the magnesium complexes of ATP Homo sapiens
2.7.2.3 ATP required as phosphate donor Homo sapiens
2.7.2.3 GTP
-
 Homo sapiens
2.7.2.3 ITP
-
 Homo sapiens