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Literature summary extracted from

  • Krygier, V.; Momparler, R.L.
    The regulatory properties of deoxyadenosine kinase (1968), Biochim. Biophys. Acta, 161, 578-580.
    View publication on PubMed

General Stability

EC Number General Stability Organism
2.7.1.76 glycerol, 50%, or dithiothreitol stabilizes Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.76 dADP 0.05 mM, 70% inhibition Bos taurus
2.7.1.76 dAMP 0.2 mM, 36% inhibition Bos taurus
2.7.1.76 dATP 0.05 mM, 68% inhibition Bos taurus
2.7.1.76 dCDP 0.001 mM, 60% inhibition Bos taurus
2.7.1.76 dCMP 0.01 mM, 88% inhibition Bos taurus
2.7.1.76 dCTP 0.0005 mM, 59% inhibition Bos taurus
2.7.1.76 deoxyguanosine substrate deoxyadenosine Bos taurus
2.7.1.76 dGDP 0.2 mM, 46% inhibition Bos taurus
2.7.1.76 dGMP 0.5 mM, 32% inhibition Bos taurus
2.7.1.76 dGTP 0.2 mM, 64% inhibition Bos taurus
2.7.1.76 additional information not inhibited by adenosine Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.76 5
-
 deoxyadenosine pH 7.8, 37°C Bos taurus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.76 Mg2+ required for activity Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.76 Bos taurus
-
 calf
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.76 streptomycin sulfate, protamine sulfate, ammonium sulfate, Sephadex G-150 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.76 thymus
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.76 additional information
-
 0.00006 mmol/ml min Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.76 ATP + deoxyadenosine transfers a phospho group from specific nucleoside 5'-triphosphate donors to 5'-position of deoxyadenosine Bos taurus ADP + dAMP
-
 ?
2.7.1.76 ATP + deoxyadenosine no activity with adenosine and guanosine Bos taurus ADP + dAMP
-
 ?
2.7.1.76 ATP + deoxyguanosine
-
 Bos taurus ADP + dGMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.76 More may be identical with EC 2.7.1.113, i.e. deoxyguanosine kinase Bos taurus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.76 37
-
 assay at Bos taurus